Updating GC/MS analytical capabilities to enhance human and animal health

项目摘要 气相色谱-质谱法(GC/MS)是一种重要的分析方法 诊断实验室中任何毒物学部分的方法学。这些分析方法是 用于筛选许多有机毒物，包括杀虫剂，并对这些毒物进行定量 分析物。家畜中农药暴露的快速识别，特别是那些农药 它可以在脂肪中积累，并可以进入人类消费的食物中，这是必不可少的 用于保护动物健康和维护食品安全标准。伴随着越来越多的担忧 关于农业恐怖主义的可能性，重要的是要裁定牲畜中的疑似病例 尽快发出或确认，以便与公众准确沟通，并 监管机构。同样，毒物学部门能够分析 牲畜饲料和宠物食品可能受到有机毒物的污染。伊利诺伊大学 密苏里州兽医诊断实验室(VMDL)毒物科目前能够 来检测一些有机毒物，但它目前的仪器是15年前的，不再 有功能正常的自动取样器，并且足够陈旧，制造商将不再维修或 修理这台设备。这一工具的当前能力显著地 限制了我们毒理学部门的方法开发和参与Vet-LIRN的能力 能力测试等活动。VMDL毒物科有很长的历史 董事会认证的兽毒学家与博士分析化学家和优秀的 技术人员为VMDL的病理学家和利益相关者提供必要的服务， 包括密苏里州农业部。VMDL的毒理学实验室很好- 设计并有足够的空间来放置拟议的仪器。收购最新的 Date GC/MS仪器将使VMDL毒物科提供更大的好处 密苏里州及其邻近各州的人类和动物健康，以及加强其 参与VET-LIRN。

Project Summary Gas Chromatography coupled with Mass Spectroscopy (GC/MS) is a critical analytical methodology for any toxicology section in a diagnostic laboratory. These analytical methods are used to screen for many organic toxicants, including pesticides, and the quantitation of these analytes. The rapid identification of pesticide exposures in livestock, especially those pesticides which can accumulate in fat and can find their way into foods consumed by humans, is essential for protecting animal health and maintaining food safety standards. With increasing concerns about the potential for agroterrorism, it is important that suspected cases in livestock be ruled out or confirmed as soon as possible to enable accurate communication with the public and regulatory agencies. Likewise, it is also important for a toxicology section to be able to analyze livestock feeds and pet food for potential contamination with organic toxicants. The University of Missouri Veterinary Medical Diagnostic Laboratory (VMDL) Toxicology Section is currently able to detect some organic toxicants, but its current instrumentation is fifteen years old, no longer has a functional autosampler, and is old enough that the manufacturer will no longer service or repair this piece of equipment. The current capabilities of this instrumentation have significantly limited our toxicology section’s abilities for method development and participation in Vet-LIRN proficiency testing and other activities. The VMDL Toxicology Section has a long history of partnering board-certified veterinary toxicologists with PhD analytical chemists and excellent technical staff to provide essential services to the VMDL’s pathologists and stakeholders, including Missouri’s Department of Agriculture. The Toxicology Laboratory in the VMDL is well- designed and has adequate space for the proposed instrumentation. The acquisition of up-to- date GC/MS instrumentation will allow the VMDL Toxicology Section to provide greater benefits to human and animal health in Missouri and its neighboring states, as well as to enhance its participation in Vet-LIRN.