Viral Vector Core

病毒载体核心是糖尿病研究中心(DRC)成员对使用感兴趣的关键资源 用于基因治疗和基础研究应用的病毒载体。载体核心提供腺病毒载体， 腺相关病毒载体(AAV)和慢病毒载体，并提供包括克隆、 DNA扩增和鉴定、载体设计和咨询。核心位于其中一个 全国首屈一指的基因治疗研究实验室，专业生产和销售 新型AAV血清型载体。DRC向量核心的目标如下：使用最先进的 设施和敬业的专业工作人员，核心将：(1)为刚果民主共和国中心成员提供进入高 基础研究和临床前研究的优质载体技术；(2)与刚果民主共和国执行委员会合作 成员开发专门供DRC成员使用的矢量；(3)使用 宾夕法尼亚大学实验室开发的用于验证和分发给DRC的卓越的核心转导配置文件 (4)为DRC成员提供载体建设和实验设计方面的咨询。这个 DRC载体核心的总体目标是为宾夕法尼亚大学和周围的科学研究人员提供服务 社区(如杰斐逊大学和坦普尔大学)，并协助推进糖尿病相关研究。

The Viral Vector Core is a critical resource for Diabetes Research Center (DRC) members interested in the use of viral vectors for gene therapy and basic research applications. The Vector core provides adenoviral vectors, adeno-associated viral vectors (AAV) and lentiviral vectors and offers a full range of services including cloning, DNA amplification and characterization, vector design, and consultation. The Core is located within one of the premier gene therapy research laboratories in the country and specializes in the production and distribution of novel AAV serotype vectors. The objectives of the DRC Vector Core are as follows: Using state-of-the-art facilities and dedicated professional staff, the Core will: (1) provide DRC Center members with access to high quality vector technologies for basic research and preclinical studies; (2) work with DRC executive committee members to develop vectors specifically for use by DRC members; (3) transition newly created vectors with superior transduction profiles developed in Penn laboratories to the Core for validation and distribution to DRC members and (4) provide consultation to DRC members for vector construction and experimental design. The overall objective of the DRC Vector Core is to serve investigators at Penn and the surrounding scientific community (e.g. Jefferson and Temple Universities) and aid in the advancement of diabetes-related research.