Administrative Core

摘要：行政核心 在接下来的5年里，南加州大学ADRC建议继续关注血管对认知的贡献 损害与阿尔茨海默病(AD)、血管和代谢危险因子(VMRF)、神经血管单位 (NVU)，以及与AD生物标志物(β-淀粉样蛋白和p-Tau)、脑结构和功能及认知的关系 (总目标1)；为非盟附属研究和南加州大学调查员发起的研究提供基础设施 临床试验(总体目标2)；在血管疾病、生物标记物和成像方面为国家 倡议(总体目标3)。行政核心将提供领导、行政机制和 监督，使我们的ADRC能够实现其总体目标。通过提供一个明确和透明的机制 通信、资源分配、预算管理和确保所有监管和患者安全 为了遵守这些程序，行政核心将进一步执行下列各项规定的总体任务 这项提案的其他组成部分。在下一个筹资周期中，亚洲发展研究中心将积极跟踪650名参与者(25% 拉丁裔)，目的是丰富高VMRF(66%)和脑血管表型的可用性 神经成像和生物流体生物标志物(例如，DCE-MRI、OCTA、TCD、血管分子生物标志物)。亚洲发展研究中心 将继续为ADRC附属研究提供基础设施和专业知识，南加州大学调查员- 启动临床试验、多中心临床研究和试验。我们的发展项目将继续 吸引和招募南加州大学的教职员工及其实习生参与南加州大学的AD研究。亚洲发展研究中心将继续作出贡献 在血管疾病、生物标记物和神经成像方面的专业知识直接用于协作的国家倡议1) 通过参与国家阿尔茨海默病协调中心(NACC)，国家中央资料库 AD(NCRAD)，阿尔茨海默病遗传学联合会(ADGC)，阿尔茨海默病神经成像倡议 (ADNI)和阿尔茨海默病临床试验联盟(ACTC)；以及2)通过与ADRC附属的几个国家和 国际独立资助的研究，如LONI，ADNI，人类连接组项目，GAAIN，谜 财团，以及多机构国家和国际项目，目前正在验证我们的新成像和 生物流体血管生物标记物。

Abstract: Administrative Core During the next 5 years, the USC ADRC proposes to continue its focus on vascular contributions to cognitive impairment and Alzheimer’s disease (AD), vascular and metabolic risk factors (VMRF), the neurovascular unit (NVU), and relationship with AD biomarkers (β-amyloid and p-Tau), brain structure and function and cognition (Overall aim 1); to provide infrastructure for ADRC-affiliated research studies and USC investigator-initiated clinical trials (Overall aim 2); and contribute expertise in vascular disease, biomarkers, and imaging to national initiatives (Overall aim 3). The Administrative Core will provide the leadership, administrative mechanisms and oversight to enable our ADRC to achieve its overall aims. By providing a clear and transparent mechanism for communication, resource allocation, budget management and insuring all regulatory and patient safety processes are adhered to, the Administrative Core will further the overall missions as described in each of the other components of this proposal. In the next funding cycle the ADRC will actively follow 650 participants (25% Latino), with the intention of enriching for high VMRF (66%) and availability of cerebrovascular phenotyping using neuroimaging and biofluid biomarkers (e.g., DCE-MRI, OCTA, TCD, vascular molecular biomarkers). The ADRC will continue to provide infrastructure and expertise for ADRC-affiliated research studies, USC investigator- initiated clinical trials, and multi-center clinical studies and trials. Our development projects will continue to engage and recruit USC faculty and their trainees into AD research at USC. The ADRC will continue contributing expertise in vascular disease, biomarkers and neuroimaging to collaborative national initiatives directly 1) through participation in the National Alzheimer Coordinating Center (NACC), National Centralized Repository for AD (NCRAD), Alzheimer Disease Genetics Consortium (ADGC), Alzheimer Disease Neuroimaging Initiative (ADNI), and the Alzheimer Clinical Trials Consortium (ACTC); and 2) via several ADRC-affiliated national and international independently-funded studies such as LONI, ADNI, Human Connectome project, GAAIN, ENIGMA Consortium, and multi-institutional national and international programs currently validating our new imaging and biofluid vascular biomarkers.