Achieving a nationally integrated food safety system: Maintaining and enhancing ISO/IEC 17025 accreditation at the CT Agricultural Experiment Station (CAES)

项目摘要 标题--“实现国家综合食品安全系统：维持和 加强CT农业试验站国际标准化组织/国际电工委员会17025认证 项目摘要-本建议书是根据RFA-FD-19-018提交的 “维持和加强国际标准化组织/国际电工委员会17025认证和全基因组测序 《国家食品检测实验室》作为竞赛A的一部分：国际标准化组织/国际电工委员会17025 认证维护和增强。康涅狄格州农业试验站 (CAES)分析化学系(DAC)在食品安全方面有144年的历史 研究，包括在FDA食品应急网络(FERN)担任成员14年 化学合作协议计划(CCAP)，根据“ISO/IEC”提供5年资助 17025：2005年食品检测实验室认可合作协议计划 (CAP)，以及2017-2019年过渡性补助金ISO CAP。在后一种方案下有两个方案， CAES DAC被美国企业协会授予国际标准化组织17025认证 2016年12月实验室认可(A2LA)，随后2017年三次范围扩大- 2019年。我们特别注意到，我们上次的评估是按照2017年的ISO标准进行的。除了……之外 作为康涅狄格州唯一为MFRPS计划提供化学测试的实验室， CAES DAC参与了一项更广泛的监督和监测计划，以确保 处于CT状态的食物。这项提议的主要目标是获得必要的资金，以 保持和加强实验室国际标准化组织/国际电工委员会17025认证，以支持食品和药物管理局 建立全国一体化的粮食体系。具体地说，这一CAP将确保化学食品 代表国家制造食品监管计划进行的分析是在 国际标准化组织/国际电工委员会17025认证实验室的范围，将加强 CAES DAC和州制造的监管计划，并将增加州的数量 每年为监测目的收集和分析的CT样本。 目前认可的实验室范围包括CAES DAC“市场篮子” 程序。这一计划是与CT消费者部门协调进行的 保护(DCP)，包括FDA MFRPS计划。目前，正在收集食物样本 每年由DCP检查员检查并带到CAES DAC进行化学分析。样品 都经过了经过验证的内部均质和提取/消化方案， 用气相色谱-质谱联用技术分析农药 高效液相色谱-高分辨质谱联用技术(LC/HRMS)。 分别用电感耦合等离子体质谱分析选定的样品中的总砷 光谱分析(电感耦合等离子体/质谱仪)。在认可范围内需要分析的食品基质包括 那些在我们的市场篮子调查中常见的产品，包括果汁、苹果酒、婴儿食品、 和其他加工水果/蔬菜。拟议中的维护和增强部分 我们的研究策略中有详细的工作，但将涉及扩大认证的范围 对于额外的食物基质，以及额外的杀虫剂和重金属。 CAES DAC已经证明了其专业知识、能力和适应性，可以完全满足 通过成功参与《国际标准化组织/国际电工委员会17025：2005》 《食品检测实验室认证》，以及随后的2017-2019年FDA ISO CAP， 以及我们14年来作为蕨类CCAP实验室的工作。接受这一新的奖项 FDA将显著增强CAES DAC的能力，特别是CT， 以达到RFA中规定的计划目标，并符合总统的食品安全规定 工作组、食品保护伙伴关系和食品安全现代化法案。

Project Summary Title- “Achieving a Nationally Integrated Food Safety System: Maintaining and Enhancing ISO/IEC 17025 Accreditation at the CT Agricultural Experiment Station” Project Summary- This proposal is being submitted in response to RFA-FD-19-018 “Maintenance and enhancement of ISO/IEC 17025 Accreditation and Whole Genome Sequencing for State Food Testing Laboratories,” specifically as part of Competition A: ISO/IEC 17025 Accreditation Maintenance and Enhancement. The Connecticut Agricultural Experiment Station (CAES) Department of Analytical Chemistry (DAC) has a 144-year history of food safety research, including 14 years as a member of the FDA Food Emergency Response Network (FERN) Chemistry Cooperative Agreement Program (cCAP), 5 years of funding under the “ISO/IEC 17025:2005 Accreditation for Food Testing Laboratories” Cooperative Agreement Program (CAP), as well as the 2017-2019 Bridge Grant ISO CAP. Under the latter program two programs, the CAES DAC was awarded ISO 17025 Accreditation by the American Association for Laboratory Accreditation (A2LA) in December 2016, followed by three scope expansions in 2017- 2019. We specifically note that our last assessment was to the 2017 ISO Standard. In addition to being the sole laboratory in Connecticut providing chemical testing for the MFRPS program, the CAES DAC participates a broader surveillance and monitoring program to ensure the safety of food in the state of CT. The primary goal of this proposal is to acquire the necessary funding to maintain and enhance the laboratories ISO/IEC 17025 accreditation so as to support FDA effort to establish a nationally integrated food system. Specifically, this CAP will ensure that chemical food analyses on behalf of the State manufactured food regulatory programs are conducted within the scope of an ISO/IEC 17025 accredited laboratory, will strengthen the collaboration between the CAES DAC and the State manufactured regulatory program, and will increase the number of State of CT samples collected and analyzed for surveillance purposes annually. The laboratories current scope of accreditation covers CAES DAC “Market Basket” program. This program is conducted in coordination with the CT Department of Consumer Protection (DCP) and includes the FDA MFRPS Program. Currently, food samples are collected annually by DCP inspectors and brought to the CAES DAC for chemical analysis. The samples are subjected to validated in-house homogenization and extraction/digestion protocols, followed by analysis for pesticides by gas chromatography with mass spectrometric detection (GC/MS/MS) and by liquid chromatography with high resolution mass spectrometric detection (LC/HRMS). Separately, select samples are analyzed for total arsenic by inductively coupled plasma mass spectrometry (ICP/MS). The food matrices to be analyzed under the scope of accreditation are those typically encountered in our Market Basket survey, which includes juices, ciders, baby food, and other processed fruits/vegetables. The maintenance and enhancement portion of the proposed work is detailed in our Research Strategy but will involve expansion of the scope of accreditation to additional food matrices, as well as to additional pesticides and heavy metals. The CAES DAC has demonstrated the expertise, capability, and adaptability to fully meet the objectives of this RFA through our successful participation in the “ISO/IEC 17025:2005 Accreditation for Food Testing Laboratories” CAP, and the subsequent 2017-2019 FDA ISO CAP, as well as through our 14 years of work as a FERN cCAP laboratory. Receipt of this new award from FDA will significantly enhance the ability of the CAES DAC specifically, and CT in general, to meet the program goals laid out in the RFA, and as described by the President’s Food Safety Working Group, the Partnership for Food Protection and the Food Safety Modernization Act.