Patient Oriented Research in Kidney Disease

 描述(申请人提供)：许志远，医学博士，硕士，正在申请续展他的以患者为中心的研究的职业中期奖(K24)，以支持他最初的研究和指导努力。K24特别支持的新研究的重点是事件终末期肾病(ESRD)。徐博士研究的一个长期主题是慢性肾脏病(CKD)，包括从CKD到ESRD的过渡，这导致了他目前对ESRD事件的兴趣。这项建议涉及我们目前如何描述新的ESRD患者，报告的新ESRD病例数量可能会受到启动肾脏替代疗法(RRT)阈值的严重影响，以及ESRD患者的早期结果如何与ESRD之前的临床事件相关。目的1：确定事件ESRD患者当前特征的准确性。目的2：量化发生终末期肾病患者的数量如何随开始慢性透析的阈值和时间的变化而变化。目的3：更好地了解ESRD发病患者的早期结局，包括早期死亡和康复，以及它们与ESRD前临床事件的关系。徐博士在加州大学旧金山分校丰富、支持和合作的机构环境中工作，有着非常出色的导师记录。继续资助K24将使许博士有更多的时间用于研究和指导，而减少行政和临床工作的时间。

 DESCRIPTION (provided by applicant): Chi-yuan Hsu, MD, MSc is applying to renew his Mid-career Investigator Award in Patient Oriented Research (K24) in order to buttress his original research and mentorship efforts. The focus of the new research to be specifically supported by this K24 is incident end-stage renal disease (ESRD). A long-standing underlying theme of Dr. Hsu's research has been chronic kidney disease (CKD), including the transition from CKD to ESRD, which leads to his current interest in incident ESRD. This proposal addresses how we currently characterize new ESRD patients, how the reported number of new ESRD cases may be heavily influenced by threshold to initiate renal replacement therapy (RRT) and how early outcomes among incident ESRD patients are related to pre-ESRD clinical events. Aim 1: To determine the accuracy of how incident ESRD patients are currently characterized. Aim 2: To quantify how the number of incident ESRD patients vary by the threshold and timing of initiation of chronic dialysis. Aim 3: To better understand early outcomes among incident ESRD patients, including early death and recovery, and how they are related to pre-ESRD clinical events. Dr. Hsu has a very strong prior track record of mentorship and works within the rich, supportive and collegial institutional environment at UCSF. Continued K24 funding will permit Dr. Hsu to spend more time on research and mentoring and less time on administrative and clinical work.