Training in Comparative Lung Biology and Medicine

项目摘要/摘要 这是对一家非常成功的比较中心的修订、竞争续订申请 呼吸生物学与医学(CCRBM)T32计划，已培训120多名预科医生 在过去的39年里，从事肺部生物学和医学研究的博士生和博士后学者。 这个博士后和博士后项目的目标是培养下一代科学家 通过跨学科的研究和课程作业，解决与 NHLBI任务。我们要求(每年)为6名博士前每人提供两年的资助。 以及从加州大学戴维斯分校的几个研究生项目和系招聘的3名博士后实习生 提供与肺部健康相关的学科培训，包括药理学、毒理学、细胞学 以及分子生物学、信息学、工程学、流行病学、免疫学和遗传学。培训 教员-来自12个系的35名活跃的研究人员-拥有丰富的指导经验 学生们。教员将指导四个主要领域的研究培训：1)肺部免疫学 和呼吸道上皮2)肺部医学中的工程和信息学；3)肺健康和 环境；4)转化性研究和治疗。我们之间的重大互动 培训教员促进肺部研究的跨学科方法。实习生有 获得先进技术，如蛋白质组学、表观/基因组学、呼吸代谢组学、状态- 最先进的成像，转基因生物，以及啮齿动物和非 人类灵长类动物。分子、细胞、组织和各种动物模型，包括非人类 灵长类动物模型，补充了来自肺、重症监护科教员的人类研究， 以及睡眠医学和比较呼吸生物学与医学中心。培训 该计划利用加州大学戴维斯分校多个研究中心的活动和资源来提供 协同作用并促进与疾病预防和公共卫生的联系；例子包括 临床和转化科学中心，加州大学戴维斯分校环境健康科学中心， NCI综合癌症中心、加州国家灵长类研究中心、NIH 小鼠生物学计划、基因组中心和美国国立卫生研究院指定的西海岸代谢组学 中心。培训计划还强调科学写作的实践指导，并 通过粉笔演讲、市政厅和 全国会议。学员接触到新兴的概念、争议和技术 通过参加该计划的研究和培训会议，包括每周一次的 CCRBM系列研讨会、其他专业研讨会系列，以及一年一度的“肺日”静修。

PROJECT SUMMARY / ABSTRACT This is a revised, competing renewal application for a highly successful Center of Comparative Respiratory Biology and Medicine (CCRBM) T32 program that has trained more than 120 pre- doctoral students and post-doctoral scholars in lung biology and medicine over the last 39 years. The objective of this pre- and post-doctoral program is to train the next generation of scientists through interdisciplinary research and coursework that addresses issues of direct relevance to the NHLBI mission. We are requesting (annually) funds for two years of support for each of 6 pre-doctoral and 3 post-doctoral trainees recruited from several UC Davis graduate programs and departments that provide disciplinary training relevant to lung health, including pharmacology, toxicology, cell and molecular biology, informatics, engineering, epidemiology, immunology and genetics. Training faculty- 35 active researchers from 12 departments- have substantial experience mentoring students. Faculty preceptors will direct research training in four primary areas: 1) Lung Immunology and the Airway Epithelium 2) Engineering and Informatics in Lung Medicine; 3) Lung Health and the Environment; 4) Translational Research and Therapeutics. Significant interactions among our training faculty members promote interdisciplinary approaches to lung research. Trainees have access to advanced technologies, such as proteomics, epi/genomics, breath metabolomics, state- of-the-art imaging, genetically modified organisms, and inhalation facilities for rodents and non- human primates. Molecular, cellular, tissue, and diverse animal models, including nonhuman primate models, complement human studies from faculty in the Division of Pulmonary, Critical Care, and Sleep Medicine and the Center for Comparative Respiratory Biology and Medicine. The training program leverages the activities and resources of multiple research centers at UC Davis to provide synergy and promote connections to disease prevention and public health; examples include the Clinical and Translational Science Center, the Environmental Health Sciences Center at UC Davis, the NCI Comprehensive Cancer Center, the California National Primate Research Center, the NIH Mouse biology program, the Genome Center, and the NIH-designated West Coast Metabolomics Center. The training program also emphasizes practical instruction in scientific writing and communication of scientific findings to peers and lay audiences through chalk talks, town halls, and national meetings. Trainees are exposed to emerging concepts, controversies, and technologies in lung health by participating in the program’s research and training conferences including the weekly CCRBM seminar series, other specialized seminar series, and the annual “Lung Day” retreat.