Translational Breast Cancer Research Training Program

摘要 乳腺癌妇女预后的改善需要一种新兴的 调查员，翻译研究员。在基础分子方面有深厚基础的科学家 而对临床疾病过程也有了解的细胞研究将指导 乳腺癌研究最有效的未来。这样的调查人员已经被召唤 “翻译”，因为他们有能力将基本发现转化为临床策略 反过来说。这种类型的培训需要资金充足的核心调查人员执行基本的 实验室研究，以及出色的临床培训计划。在贝勒医学院， 乳房中心提供了这样的组合。这是一份正式培训的新申请书 该计划始于1999年，当时成立了现在的史密斯乳房中心。所有受训人员 乳腺癌研究的一个重点方面，包括1)激素作用/内分泌 治疗2)分子基因组学3)生长因子/信号转导4)正常乳腺 开发/预防乳腺癌和5)新的治疗策略。正式 教学课程包括科学写作、研究资助、生物统计学、领导技能、 分子致癌，临床转化型乳腺癌研究中存在的问题有 必填项。学员的研究项目的进展和方向受到密切关注 每两个月举办一次研究和开发讲习班。

Abstract Improvements in the outcome for women with breast cancer require an emerging new breed of investigator, the translational researcher. Scientists with a strong foundation in basic molecular and cellular research who also have an understanding of the clinical disease course will direct the most effective future of breast cancer research. Such investigators have been called “translational” because of their ability to translate basic findings into clinical strategies and vice versa. This type of training requires both a well-funded core of investigators performing basic laboratory research, and an excellent clinical training program. At Baylor College of Medicine, the Breast Center affords such a combination. This is a new application for a formal Training Program that began in 1999 when what is now the Smith Breast Center was formed. All trainees work on a focused aspect of breast cancer research including 1)Hormone Action/Endocrine Therapy 2)Molecular Genomics 3)Growth Factors/Signal Transduction 4)Normal Breast Development/Breast Cancer Prevention and 5)Novel Treatment Strategies. Formal didactic courses covering Scientific writing, research grants, Biostatistics, Leadership skills, Molecular carcinogenesis, and problems in clinical translational breast cancer research are required. Progress and direction of the trainee's research project are closely monitored in bimonthly Research and Development workshops.