Patients Registry-Virtual Biorepository Core

项目摘要 患者登记和生物储存库旨在为数据提供最佳基础设施 收集和存档，数据共享和生物标本资源分配，以促进 成功完成拟议的研究项目以及未来的试点和跨BETRNet项目。 哥伦比亚-宾夕法尼亚大学-马约患者登记和生物储存库的基础数据库设计为 与BETRNet协调中心维护的中央系统无缝集成， 便于与其他BETRNet研究中心合作。该系统旨在有效地 将数据库转移到BETRNet协调中心，并在多个地点传播结果。的 组织库是基于一个大型的、长期存在的食管癌手术切除组织库。 这个哥伦比亚-梅奥-宾夕法尼亚患者登记和生物储存库将作为三个独特的资源， 将在拟议资助期内开展的项目，以及与以下方面有关的未来项目 食管腺癌该系统是专门为实现以下目标而设计的： 促进与BE发展及其向EAC进展相关的研究;将这些发现转化为 患者水平的风险分层和化学预防生物标志物;并最终减少 EAC在人群水平的发病率和死亡率。现有的项目网站，其中包括一个链接 允许直接访问BETRNet协调中心，将定期更新，包括 发布研究成果，并提供对已发表论文的访问。基于Web的数据请求表将 也可以添加，以便于向调查人员提供数据。

PROJECT SUMMARY The Patient Registry and Biorepository has been designed to provide an optimal infrastructure for data collection and archiving, data sharing, and biospecimen resource distribution in order to facilitate the successful completion of the proposed Research projects as well as future Pilot and Cross-BETRNet Projects. The database underlying the Columbia-UPenn-Mayo Patient Registry and Biorepository has been designed to integrate seamlessly with the central system maintained at the BETRNet Coordinating Center and to maximize ease of collaboration with other BETRNet Research Centers. The system has been designed to efficiently transfer database to BETRNet Coordinating Center and to disseminate results among multiple venues. The tissue repository is based on a large, long-standing tissue bank of surgical resections for esophageal cancer. This Columbia-Mayo-Penn Patient Registry and Biorepository will serve as a unique resource for the three projects that will be carried out during the proposed funding period, as well as for future projects related to esophageal adenocarcinoma. The system has been designed specifically to achieve the following goals: facilitating research related to the development of BE and its progression to EAC; translating these findings to the patient-level with regards to biomarkers for risk stratification and chemoprevention; and ultimately reducing the morbidity and mortality of EAC at a population level. The existing project website, which includes a link allowing direct access to the BETRNet Coordinating Center, will be updated on a regular basis to include postings of research results and provide access to published papers. A web-based Data Request form will also be added to faciitate the delivery of data to investigators.