Advanced Training in Environmental Health Sciences

项目总结 这是一个非常成功的T32计划的竞争续签申请，该计划已培训了180多人 在过去的45年里，毒理学/环境健康科学(EHS)的博士前学生。的目标是 这个博士前项目旨在通过跨学科的方式培养下一代环境健康科学家 解决与NIEHS任务直接相关的问题的研究和课程工作。我们要求的是2 为8名博士前实习生在博士学位第一年或第二年后开始的每人提供多年的支持 程序。受训者来自加州大学戴维斯分校的几个提供纪律培训的研究生项目 与EHS相关的学科，包括毒理学、细胞和分子生物学、暴露评估、流行病学、 神经科学、免疫学和遗传学。培训教员-来自19个系的32名现役研究人员-有 有丰富的博士后辅导经验。教师研究的重点是通过什么机制 环境因素导致人类疾病，并涵盖EHS内的不同领域，包括 呼吸毒理学、癌症、神经毒理学、遗传毒性、表观遗传学和代谢紊乱。意义重大 培训教员之间的互动促进了EHS研究的跨学科方法。实习生 能够获得先进的技术，如蛋白质组学、表观/基因组学和代谢组学、最先进的 为啮齿动物和非人类灵长类动物提供成像、转基因生物和吸入设施。一种力量 加州大学戴维斯分校EHS研究的重点是垂直整合的研究，旨在了解环境 诱发疾病。分子、细胞、组织和各种动物模型，包括非人类灵长类动物模型， 补充通过加州大学戴维斯临床和翻译科学中心获得的人类临床样本 (CTSC)和流行病学研究。培训计划利用多个组织的活动和资源 加州大学戴维斯分校的研究中心将提供协同效应并促进与疾病预防和公众的联系 健康；例子包括加州大学戴维斯分校的NIEHS P30环境健康科学核心中心 研究所，儿童环境健康中心，NCI综合癌症中心，西部癌症中心 农业健康与安全、NIEHS超级基金计划和NIEHS纳米技术健康中心 影响研究。培训计划强调科学写作的实践指导，并 通过粉笔演讲、年度静修、市政厅、 以及全国性的会议。学员还可以接触到新兴的概念、争议和技术 通过参加由实习生组织和管理的研讨会系列来实现环境健康 来自全国各地的环境健康科学家，以及通过师生互动在一个 暑期课程，学员在以下指导下探讨当前与环境健康有关的问题 培训教员。受训者将接受负责任地进行研究的培训。培训计划的基础是 在培训学术界、政府和私营部门的EHS领导者方面有良好的记录。

PROJECT SUMMARY This is a competing renewal application for a highly successful T32 program that has trained more than 180 predoctoral students in toxicology/environmental health sciences (EHS) over the last 45 years. The objective of this predoctoral program is to train the next generation of environmental health scientists through interdisciplinary research and coursework that address issues of direct relevance to the NIEHS mission. We are requesting 2 years of support for each of 8 predoctoral trainees beginning after their first or second year in a PhD degree program. Trainees are recruited from several UC Davis graduate programs that provide disciplinary training relevant to EHS, including toxicology, cell and molecular biology, exposure assessment, epidemiology, neuroscience, immunology and genetics. Training faculty — 32 active researchers from 19 departments — have substantial experience mentoring predoctoral students. Faculty research focuses on mechanisms by which environmental factors contribute to human disease and encompasses diverse areas within EHS, including respiratory toxicology, cancer, neurotoxicology, genotoxicity, epigenetics, and metabolic disorders. Significant interactions between training faculty members promote interdisciplinary approaches to EHS research. Trainees have access to advanced technologies, such as proteomics, epi/genomics and metabolomics, state-of-the-art imaging, genetically modified organisms, and inhalation facilities for rodents and non-human primates. A strength of EHS research at UC Davis is the vertical integration of studies directed toward understanding environmentally induced disease. Molecular, cellular, tissue, and diverse animal models, including nonhuman primate models, complement human clinical samples obtained through the UC Davis Clinical and Translational Science Center (CTSC) and epidemiologic studies. The training program leverages the activities and resources of multiple research centers at UC Davis to provide synergy and promote connections to disease prevention and public health; examples include the NIEHS P30 Environmental Health Sciences Core Center at UC Davis, the MIND Institute, Center for Children's Environmental Health, NCI Comprehensive Cancer Center, Western Center for Agricultural Health and Safety, NIEHS Superfund Program and the NIEHS Center for Nanotechnology Health Implications Research. The training program emphasizes practical instruction in scientific writing and communication of scientific findings to peers and lay audiences through chalk talks, annual retreats, town halls, and national meetings. Trainees are also exposed to emerging concepts, controversies, and technologies in environmental health by participating in a trainee-organized and -managed seminar series that hosts leading environmental health scientists from across the country, as well as through faculty–student interactions during a summer course in which trainees explore a current issue relevant to environmental health under the guidance of training faculty. Trainees will receive training in responsible conduct of research. The training program builds on an excellent track record of training leaders in EHS in academia, government, and the private sector.