Brain Networks and Mobility Function: B-NET

项目总结/摘要 活动功能下降是一种常见的年龄相关现象，与生活质量下降有关 社会成本高。最近，大脑在运动功能中的关键作用已经被认识到， 评估白色物质特征的成像方法。一种新的范式，将大脑视为 复杂网络使用MRI直接将大脑表征为功能网络。大脑网络和 移动功能：B-NET汇集了脑网络科学，神经病学和移动性方面的国家领导人 评估应用这种创新的网络范式来阐明大脑老化在流动性下降中的作用。 我们认为感觉运动皮层内部和之间的功能连接--社区结构 （SMC-CS）-预测流动性下降; SMC-CS将与流动性相关， 白色物质完整性和移动功能之间的已知关系。 B-Net将建立一个由240名居住在社区的老年人（年龄范围为70-85岁）组成的队列，并测量流动性 使用扩展的短期体能测试组合（eSPPB）在基线、6、18和30个月时评估功能。的 将在30个月时重复MRI。B-Net的具体目标是： 具体目标1。确定SMC-CS和eSPPB评分之间的基线相关性。我们假设 SMC-CS将与独立于移动性功能的已知相关性的eSPPB性能相关联 和白色物质完整性（即分数各向异性和白色物质损伤）。 具体目标2。确定基线SMC-CS是否可预测活动能力下降。我们假设穷人 基线SMC-CS将在考虑已知的活动性相关性后预测eSPPB评分下降 损害包括白色物质完整性、心血管健康和肌肉力量。 具体目标3。重复脑MRI成像，以确定脑组织变化之间的纵向关联。 SMC-CS和eSPPB评分变化。我们假设SMC-CS的纵向下降将是 与eSPPB性能下降显著相关，与下肢的已知相关性无关 功能衰退和白色物质完整。 B-NET测试了一种关于CNS在年龄相关功能衰退中的作用的新的新兴范式，以支持 制定创新战略，以维持老年人的行动功能，这是一个重要的公共卫生问题， 需要的

Project Summary/Abstract Declining mobility function is a common age-related phenomenon that is associated with reduced quality of life and high societal costs. Recently, the brain's critical role in mobility function has been recognized using imaging approaches assessing white matter characteristics. A new paradigm considering the brain as a complex network uses MRI to directly characterize the brain as a functional network. Brain Networks and Mobility Function: B-NET brings together national leaders in brain network science, neurology and mobility assessment to apply this innovative network paradigm to elucidate the aging brain's role in declining mobility. We propose that functional connectivity within and between the sensorimotor cortex -- community structure (SMC-CS) -- predicts declining mobility; and that SMC-CS will be associated with mobility independent of known relationships between white matter integrity and mobility function. B-Net will establish a cohort of 240 community-dwelling older adults (age range 70-85) and measure mobility function at baseline, 6, 18 and 30 months using the extended short physical performance battery (eSPPB). The MRI will be repeated at 30 months. B-Net's specific aims are to: Specific Aim 1. Determine the baseline association between SMC-CS and eSPPB score. We hypothesize that SMC-CS will be associated with eSPPB performance independent of known correlates of mobility function and white matter integrity (i.e. fractional anisotropy and white matter lesions). Specific Aim 2. Determine whether baseline SMC-CS predicts mobility decline. We hypothesize that poorer baseline SMC-CS will be predict declining eSPPB scores after accounting for known correlates of mobility impairment including white matter integrity, cardiovascular fitness, and muscle strength. Specific Aim 3. Repeat brain MRI imaging to determine the longitudinal association between changes in SMC-CS and changes in eSPPB score. We hypothesize that longitudinal declines in SMC-CS will be significantly associated with declining eSPPB performance independent of known correlates of lower extremity function decline and white matter integrity. B-NET tests a novel emerging paradigm regarding the CNS's role in age-related functional decline to support the development of innovative strategies to sustain mobility function in older adults, a critical public health need.