Completely biological tissue-engineered pulmonic valve grown in vitro from human cells for pediatric patients

摘要 该项目的目标是创造一种可以与儿童一起成长、永远不需要替换的心脏瓣膜。 使用生物工程的胶原质基质，其形式为管状，已被证明生长为 羔羊的肺动脉置换，以及由这些管子制成的心脏瓣膜的新设计和 可降解缝合线，可提供持久的愈合以及瓣膜生长潜力，我们将设计， 在幼年绵羊模型中优化、测试和植入三管瓣膜，以演示瓣膜生长。目标1将 使用计算机辅助设计(阀门开度的流固耦合模型和阀门开度的有限元模型 阀门关闭状态)以筛选设计参数的组合(定义接合面积和几何形状) 为了高效的阀门功能，Aim 2将在脉冲复制器中测试优化设计，并验证/改进CAD 模型和目标3将涉及在成长中的绵羊的瓣膜的研究。肺损伤的长期研究进展 和主动脉瓣置换术都是为严格解决瓣膜生长问题而设计的。

Abstract The goal of this project is to create a heart valve that can grow with children and never require replacement. Using a biologically-engineered collagenous matrix in the form of a tube that has been shown to grow as a pulmonary artery replacement in lambs, and a novel design for a heart valve made from these tubes and degradable suture that confers durable commissures as well as valve growth potential, we will design, optimize, test, and implant tri-tube valves in a juvenile sheep model to demonstrate valve growth. Aim 1 will use computer-aided design (a fluid-structure interaction model for valve opening and finite element model for the closed valve state) to screen combinations of design parameters (defining coaptation area and geometry) for efficient valve function, Aim 2 will test the optimal designs in a pulse duplicator and validate/refine the CAD models, and Aim 3 will involve studies of the valve in growing juvenile sheep. Long-term studies of pulmonary and aortic valve replacement are designed with measurements to rigorously address valve growth.