Exposure Biology Informatics Facility Core

暴露生物信息学核心(EBIC)：摘要 暴露生物学信息学核心(EBIC)致力于为CEET提供信息学支持 化学信息学资源管理和分析、生物信息学应用领域的研究人员 开发、多组学数据管理和集成、下一代测序(NGS)数据分析、 从电子健康记录(EHR)中提取数据的生物医学信息学、计算机编程、 人工智能和机器学习，以及数据可视化。为此，我们已经组建了一个 拥有计算机科学、数据科学和基因组学互补技能的不同专家团队，以构建 强大的信息基础设施，为生物医学和环境大数据做好准备。的愿景 EBIC将为常规使用创新计算方法提供无缝支持，这些方法包括 暴露生物学和环境健康的复杂性，并使大数据能够转化为知识 推进精准公共卫生(PPH)。EBIC的一个中心目标是与CEET调查人员密切合作 发挥协作和支持作用，以了解不良结果路径(AOP)或 从接触分子启动事件到下游关键事件再到生物体和种群健康 结果。EBIC的主要目标围绕八个具体目标组织。目标1：我们将提供 为研究小组提供最先进的信息学服务，否则他们将无法访问这些计算 接近了。在目标2：我们将支持CEET在空气污染、肺健康、环境方面的主题领域 暴露与癌症，易感之窗，环境神经科学与信息学服务。在……里面 目标3：我们将通过优先排序来优化EBIC服务。目标4：我们将支持CEET试点项目 信息学服务部门。在目标5中：我们将提供使用最先进的计算设备和 软件。在目标6：我们将确保EBIC支持综合保健科学基金的活动 CORE和翻译生物标记物核心，为人类主体/人口研究提供信息学支持。在……里面 目标7：我们将提供信息学的教育机会和培训，这是一种可选的经验 早期调查人员。在目标8中：我们将向更大的群体传播信息学、数据软件和新工具 环境健康科学界。

EXPOSURE BIOLOGY INFORMATICS CORE (EBIC): ABSTRACT The Exposure Biology Informatics Core (EBIC) is dedicated to providing informatics support to CEET investigators in the areas of chemoinformatics resource management and analysis, bioinformatics application development, multi-omics data management and integration, next-generation sequencing (NGS) data analysis, biomedical informatics to extract data from the Electronic Health Record (EHR), computer programming, artificial intelligence and machine learning, and data visualization. For this purpose, we have assembled a diverse team of experts with complementary skills in computer science, data science, and genomics to build a powerful informatics infrastructure that is prepared for biomedical and environmental big-data. The vision for EBIC is to provide seamless support for routine use of innovative computational methods that embrace the complexity of exposure biology and environmental health and enable the conversion of big-data into knowledge to advance Precision Public Health (PPH). A central goal of the EBIC is to work closely with CEET investigators in both a collaborative and support role to understand adverse outcome pathways (AOP) or constructs that go from the exposure to molecular initiating events to downstream key events to organism and population health outcomes. The primary objectives of the EBIC are organized around eight specific aims. In Aim 1: we will provide state-of-art informatics services to research groups that otherwise would not have access to these computational approaches. In Aim 2: We will support the CEET thematic areas in Air Pollution & Lung Health, Environmental Exposures & Cancer, Windows-of-Susceptibility, and Environmental Neuroscience with informatics services. In Aim 3: We will optimize EBIC services through prioritization. In Aim 4: We will support the CEET pilot projects with informatics services. In Aim 5: We will provide access to state-of-the-art computational equipment and software. In Aim 6: We will ensure that EBIC supports the activities of the Integrative Health Sciences Facility Core and the Translational Biomarker Core with informatics support for human subject/population research. In Aim 7: We will provide educational opportunities and training in informatics which is an optional experience for Early Stage Investigators. In Aim 8: We will disseminate informatics, data software and new tools to the larger environmental health sciences community .