Nurses Health Study 3: A multiple exposure environmental epidemiology cohort of young adults

项目总结 这是一个R24应用程序，用于支持我们的环境流行病学队列护士的基础设施 健康研究3(NHS3)，一个开放的、前瞻性的、基于网络的队列(www.nhs3.org)。参与者为居住地 出生于1965年后的美国和加拿大。大多数女性参与者(89%)以前注册过 更年期，41%的女性参与者和62%的男性参与者没有孕产史。在……里面 这项创新的基于网络的研究，我们一直在收集关于个人特征和 每6个月潜在的疾病风险因素，包括饮食、体力活动、心理社会因素和广泛的 各种职业和环境暴露。数据收集侧重于当前的风险敞口，因为 以及青春期、第一次怀孕前和怀孕期间经历的那些。新发现 Made in NHS3将建立在从早期队列中获得的关于 环境对慢性病风险的影响，但利用现代技术收集新的前景 在整个生命过程中的重要接触窗口期间的数据。NHS3的调查人员有大量的 环境流行病学、暴露评估和大数据分析方面的经验，以及 管理和维护大型前瞻性队列研究。这一群体提供了一个独特的机会 通过收集关于环境流行病学的高度详细的信息，解决环境流行病学中的关键悬而未决的问题 生命过程中关键时刻的多次环境暴露。 在此，我们建议支持扩展的NHS3队列中的基础设施活动，以最大限度地提高现有 资源和拓宽目前的研究范围，使多环境调查成为可能 曝光。我们将重点在三个方面下功夫：1)扩大学习活动和 最大限度地利用现有资源，2)收集环境暴露样本，3)扩大 基于网络的移动技术以及空间不确定度和测量误差的评估。

PROJECT SUMMARY This is an R24 application to support the infrastructure of our environmental epidemiology cohort, Nurses’ Health Study 3 (NHS3), an open, prospective, web-based cohort (www.nhs3.org). Participants are residence of the United States and Canada born after 1965. Most of the female participants (89%) have enrolled before menopause and 41% of female participants and 62% of male participants have no prior pregnancy history. In this innovative web-based study, we have been collecting detailed information on personal characteristics and potential disease risk factors every 6 months, including diet, physical activity, psychosocial factors, and a wide variety of occupational and environmental exposures. Data collection has focused on current exposures, as well as those experienced during adolescence, prior to first pregnancy, and during pregnancy. Discoveries made in NHS3 will build on the knowledge and experience gained from earlier cohorts on the impacts of the environment on chronic disease risk, but takes advantage of modern technology to collect novel prospective data during important windows of exposure across the life course. The NHS3 investigators have substantial experience in environmental epidemiology, exposure assessment, and Big Data analytics, as well as in managing and maintaining large prospective cohort studies. This cohort provides a unique opportunity to address key outstanding questions in environmental epidemiology, by collecting highly detailed information on multiple environmental exposures at key points in the life course. Here, we propose to support infrastructure activities in the expanded NHS3 cohort that maximize the existing resources and broaden the current scope of research, to allow the investigation of multiple environmental exposures. We will focus our efforts in three main areas: 1) the expansion of study operations and maximization of existing resources, 2) the collection of environmental exposure samples, and 3) expansion of web-based mobile technologies and assessment of spatial uncertainty and measurement error.