Mouse Models Core D

鼠标型号核心D项目总结 克利夫兰DDRCC鼠标模型核心的目标是提供一套全面的具有成本效益的 为DDRCC研究人员提供服务和共享资源，以增强他们在活体研究中的表现 重点阐述了消化系统炎症/肿瘤和肝病/代谢的发病机制。这个 这一核心的总体目标是提供集中化的鼠标建模服务，以加快体内建模的速度 凯斯西储大学和克利夫兰诊所的消化系统疾病相关研究 研究机构，并提供公共的、经济高效的肠道上独特的小鼠模型 炎症和肝病，从而产生新的研究项目、资助机会和 在这些调查领域的合作。在过去的筹资周期中，核心项目取得了成功， 核心用户数量增加，一些重要出版物得到核心用户的支持。这个 克利夫兰DDRCC鼠标模型核心通过以下具体目标实现这些目标：(1)提供 SAMP1/YitFc和肿瘤坏死因子的实验队列是对中心成员、其他DDRCC和美国的小鼠 科学界；(2)教育、咨询和培训发改委调查人员使用各种鼠标 建模技术；(3)提供高分辨率的小鼠视频内窥镜检查，并对 肠道炎症和结肠肿瘤；(4)三维定量检测小鼠肠道炎症 立体显微镜和髓过氧化物酶活性的评估；以及(5)与病例小鼠的接口 代谢表型中心支持DDRCC研究人员进行小鼠代谢研究和 提供有关可用于研究小鼠炎症和免疫缺陷的新技术的联合教育计划 代谢性疾病。DDRCC鼠标模型核心指导委员会每月开会讨论 运营问题。核心向DDRCC执行委员会每季度介绍其业务情况 根据复员方案协调委员会不断变化的需求评价现有服务的有效性的会议 让核心为中心成员和中心的科学主题带来最大利益 克利夫兰DDRCC。因此，Mouse Models Core通过提供以下组合使DDRCC成员受益 独特的可用资源和成本效益高的服务，促进与以下方面相关的研究的发展 克利夫兰科学界和其他地方的消化系统疾病。

MOUSE MODELS CORE D PROJECT SUMMARY The objective of the Cleveland DDRCC Mouse Models Core is to provide a comprehensive set of cost-effective services and shared resources to DDRCC investigators that augments their performance of in vivo studies focused on the pathogenesis of Digestive Inflammation/Tumorigenesis and Liver Disease/Metabolism. The overall goal of this Core is to provide centralized mouse modeling services that will enhance the pace of in vivo digestive disease-related research at Case Western Reserve University and the Cleveland Clinic Lerner Research Institute and provide communal, cost-effective access to unique mouse models on intestinal inflammation and liver disease, thus resulting in new research projects, funding opportunities, and collaborations in these areas of investigation. During the past funding cycle, the Core has been successful, with an increase in the number of Core users and several important publications supported by the Core. The Cleveland DDRCC Mouse Models Core achieves these goals through the following specific aims: (1) Provide experimental cohorts of SAMP1/YitFc and TNFARE mice to Center members, other DDRCCs, and the US scientific community; (2) Educate, consult, and train DDRCC investigators in the use of various mouse modeling techniques; (3) Provide high-resolution murine video endoscopy with well-validated scoring of intestinal inflammation and colonic tumors; (4) Quantify murine intestinal inflammation by 3-D stereomicroscopy with assessment of myeloperoxidase activity; and (5) Interface with the Case Mouse Metabolic Phenotyping Center to support DDRCC investigators performing murine metabolic studies and provide joint educational programs on new technologies available for the study of murine inflammatory and metabolic diseases. The DDRCC Mouse Models Core Steering Committee meets monthly to discuss operational issues. The Core presents its operations to the DDRCC Executive Committee at their quarterly meetings to evaluate the effectiveness of existing services against the evolving needs of the DDRCC membership so that the Core brings the most benefit to the Center members and the scientific themes of the Cleveland DDRCC. Thus, the Mouse Models Core benefits DDRCC members by providing a combination of uniquely available resources and cost-effective services that facilitate the development of research related to digestive diseases in the Cleveland scientific community and beyond.