Integrated Health Sciences Facility Core

摘要：综合健康科学中心 休斯顿-加尔维斯顿地区是十几个超级基金的所在地，也是石化工业的中心 拥有500家化工厂，10家炼油厂和超过6000英里的石油，天然气和化学品管道， 最大的能源走廊。该地区也是世界上最大的医疗中心德克萨斯州的所在地 医学中心因此，无论是需要和机会的大小，为NIEHS环境健康科学 (EHS)核心中心（EHS-CC）在这个地区是伟大的。作为德克萨斯医疗中心的EHS-CC，海湾 海岸精密环境健康中心（GC-CPEH）将成为有影响力的 EHS研究，与当地社区和利益相关者的双向沟通，以及发动机驱动 翻译精确的环境健康研究进展，以改善人类健康。集成 健康科学设施核心（IHSFC）旨在为中心成员提供支持， 通过利用独特的资源，进行有影响力的转化环境健康科学（EHS）研究， 社区伙伴关系在三个GC-CPEH母机构：贝勒医学院（马里兰州）， UTHealth公共卫生学院（UTH-SPH）和德克萨斯大学医学分支（UTMB）。的指导 IHSFC的愿景是促进成员研究的正向和反向转化，以促进健康， 减少对环境相关的不良健康后果的敏感性。主要目标是提供 无缝访问GC-CPEH成员的基础研究翻译的专业知识和能力 科学纳入人口研究，并促进"反向翻译"人口研究的结果， 基础和临床研究转变为新的假设驱动的实验室研究。为了实现这一目标，IHSFC将 使用“翻译导航”将GC-CPEH成员与IHSFC专业知识和服务联系起来， 促进该中心的主题重点领域的转化环境健康研究：早期生活 遗传和表观遗传环境（GE2）的相互作用;灾害研究响应（DR2）;和识别 人类环境疾病的机制和干预措施（MIHED）。IHSFC组件包括： 1)人口科学; 2）临床科学; 3）暴露评估; 4）生物标志物和5）社区 订婚这些组成部分得到GC-CPEH中各种独特资源的支持， 包括一个移动的临床研究单位，环境卫生服务诊所，生物储存库，生物医学 地理空间建模分析设施和分析实验室，用于环境和生物标志物评估。

ABSTRACT: INTEGRATED HEALTH SCIENCES FACILITY CORE The Houston-Galveston area is home to over a dozen Superfund sites, and a hub for the petrochemical industry with 500 chemical plants, 10 refineries and >6000 miles of oil, gas and chemical pipelines in what has become the country’s largest energy corridor. The area is also home to the largest medical center in the world, the Texas Medical Center. Thus, both the need and size of the opportunity, for an NIEHS Environmental Health Sciences (EHS) Core Center (EHS-CC) in this region is great. As the EHS-CC for the Texas Medical Center, the Gulf Coast Center for Precision Environmental Health (GC-CPEH) will be the focal point and catalyst for impactful EHS research, bi-directional communication with local communities and stakeholders, and the engine driving translation of precision environmental health research advances to improve human health. The Integrated Health Sciences Facility Core (IHSFC) was developed to provide Center members with support to conduct impactful translational environmental health sciences (EHS) research by leveraging unique resources and community partnerships across the three GC-CPEH parent institutions: Baylor College of Medicine (BCM), UTHealth School of Public Health (UTH-SPH), and University of Texas Medical Branch (UTMB). The guiding Vision for the IHSFC is to facilitate forward and reverse translation of members’ research to promote health and reduce susceptibility to environmentally-related adverse health outcomes. The primary Goal is to provide seamless access to expertise and capabilities for translation of GC-CPEH members’ research in the basic sciences into human population studies, and facilitate “reverse translation” of findings from human-population based and clinical studies into new hypothesis-driven laboratory research. To achieve this Goal, the IHSFC will use “Translational Navigators” to connect GC-CPEH Members to IHSFC expertise and services and promote translational environmental health research of the Thematic Focus Areas of the Center: Early Life Genetic and Epigenetic Environment (GE2) Interactions; Disaster Research Response (DR2); and Identification of Mechanisms of, and Interventions for, Human Environmental Disease (MIHED). IHSFC components include: 1) Population Sciences; 2) Clinical Sciences: 3) Exposure Assessment; 4) Biomarkers and 5) Community Engagement. These components are supported by diverse and unique resources across the GC-CPEH, including a Mobile Clinical Research Unit, Environmental Health Service Clinics, Biorepositories, a Biomedical Geospatial Modeling Analytics Facility and Analytical Laboratories for environmental and biomarker assessment.