Core C: Biosecurity Core

项目总结/摘要 该项目的目标是保持加尔维斯顿国家实验室（GNL）在 德克萨斯大学医学分支作为NIAID生物防御设施网络的一部分 为NIAID资助的最大遏制研究设施提供使用权 来自全国各地和世界各地的研究人员，学术合作者， 商业伙伴和其他适当的。这种高遏制研究 需要基础设施和相关设施来安全可靠地进行 研究，这将有助于发现和发展的治疗，诊断 以及需要生物防护的危险病原体的疫苗。这一独特的资源 也是教育下一代传染病专家的重要资源。 对全球健康具有重要意义的疾病。GNL积极响应国家公众 通过提供快速诊断援助，分享关键的 试剂，并有助于发现和开发有效的医疗 对策为了实现这一目标，GNL维护的核心重点是支持 安全和可靠的操作和维护最大限度的遏制研究 设施，并提供独特的资源和工具，以调查工作， 生物遏制，使他们能够快速，安全和可靠地解决新兴的 传染病和生物恐怖主义威胁。独特的功能包括： 生成并量化实验室动物（从小鼠到非人类）的气溶胶激发 灵长类动物，利用节肢动物媒介群传播人畜共患病 研究和最先进的成像能力，以可视化的结果，其中许多 他人GNL团队共同开展基础和应用研究， 将原始发现从概念过渡到最终产品开发、验证和 执照

Project Summary/Abstract The goal of this project is to maintain the Galveston National Laboratory (GNL) at the University of Texas Medical Branch as a part of the NIAID Biodefense Facilities Network to provide access to maximum containment research facilities for NIAID funded investigators, academic collaborators from across the nation and around the world, commercial partners and others as appropriate. This high containment research infrastructure and associated facilities is required to safely and securely conduct research that will facilitate the discovery and development of therapeutics, diagnostics and vaccines for dangerous pathogens requiring biocontainment. This unique resource is also a critical resource to educate the next generation of experts in infectious diseases of global health importance. The GNL actively responds to national public health emergencies by providing rapid assistance in diagnostics, sharing of critical reagents, and contributing to the discovery and development of effective medical countermeasures. To achieve this goal, the GNL maintains cores focused on supporting safe and secure operations and maintenance of maximum containment research facilities and to provide unique resources and tools to investigators working in biocontainment to allow them to rapidly, safely and securely address emerging infectious diseases and bioterrorism threats. Unique capabilities include the ability to generate and quantify aerosol challenges of laboratory animals from mice to non-human primates, access to arthropod vector colonies to support zoonotic disease transmission studies, and state-of-the-art imaging capabilities to visualize findings, among many others. Working together, GNL teams conduct basic and applied research that can transition original discoveries from concept to final product development, validation and licensure.