Claude D. Pepper Older Americans Independence Centers (OAICs)(P30)

摘要 在这次竞争性的续约申请中，密歇根大学的克劳德·D·Pepper美国老年人 独立中心（UM胡椒中心），成立于1989年，旨在提供科学的领导和 衰老研究的创新，以解决核心假设，靶向代谢和炎症 因素作为老年疾病和结果的关键介质，可改善患者的身体和认知功能， 老年人 UM胡椒中心的首要目标是创造，增强和保持一个有凝聚力的知识分子， 技术和行政环境，以最大限度地提高老年医学研究，这将促进健康， 老年人的功能独立。UM胡椒中心将在五个目标中追求其目标。目标1） 为了支持研究，解决中心的重点，以提高对代谢因素的理解， 炎症决定了与活动性和功能状态相关的关键健康结果。目标2）支持 代谢因子和炎症与年龄相关疾病相互作用的转化研究， 合并症，以改善与活动性和功能状态相关的健康结果。为了达到这个目标， Pepper中心将与密歇根大学的其他项目密切合作，包括密歇根临床与健康研究所 研究（MICHR），UM临床和转化科学奖（CTSA）的所在地。目标3） 提供资源核心，以支持和协助与UM Pepper相关的决策者发起的项目 中心的研究重点。目标4）通过其研究教育核心（REC），加强UM 培养未来老年医学和老龄化学术领导者的环境，他们可以进行与以下方面有关的研究： 辣椒中心的研究重点。目标5）通过其试点和探索性研究核心（PESC）， 吸引UM教师开发与UM Pepper中心研究重点相关的新研究项目。 UM胡椒中心有一个完善的领导和行政结构，一个REC， PESC和四个RC：人类主体和评估核心（HSAC）;生物力学核心（BC）; 设计、数据和生物统计学核心（DDBC）和老年啮齿动物核心设施（CFAR）。所述REC 具有三个核心要素：1）每年选择2名有前途的UM初级教师的竞争计划， 进行与UM Pepper中心研究相关的研究，并保证50%的精力用于研究事业 发展; 2）为从事此类研究的初级教师提供国家认可的研究培训计划， 和3）一个导师计划，增加机会，初级教师密切合作， 或更多高级研究员。PESC将通过利用OAIC每年资助5个或更多的试点项目 与其他多个UM机构资源的资金。驻地协调员将支持多个外部供资的项目， 胡椒中心试点赠款和REC初级教师，并继续开发和测试新的方法， 用于胡椒中心的研究

Abstract In this competitive renewal application, the University of Michigan Claude D. Pepper Older Americans Independence Center (UM Pepper Center), established in 1989, seeks to provide scientific leadership and innovation for aging research to address the central hypothesis that targeting metabolic and inflammatory factors as critical mediators of geriatric conditions and outcomes improves physical and cognitive functions of older adults. The overarching goal of the UM Pepper Center is to create, enhance and maintain a cohesive intellectual, technological, and administrative environment to maximize geriatrics research that will promote health and functional independence in older adults. The UM Pepper Center will pursue its objectives in five Aims. Aim 1) To support research that addresses the Center’s focus to improve understanding of how metabolic factors and inflammation determine key health outcomes related to mobility and functional status. Aim 2) To support translational research on the interaction of metabolic factors and inflammation with age-related diseases and comorbidities to improve health outcomes related to mobility and functional status. To achieve the aim, the UM Pepper Center will work closely with other UM programs including the Michigan Institute for Clinical and Health Research (MICHR), the home of the UM’s Clinical and Translational Science Award (CTSA). Aim 3) To provide Resource Cores that support and assist investigator-initiated projects related to the UM Pepper Center’s research focus. Aim 4) Through its Research Education Core (REC), to strengthen the UM environment for training of future academic leaders in geriatrics and aging who can conduct research related to the UM Pepper Center’s research focus. Aim 5) Through its Pilot and Exploratory Studies Core (PESC), to attract UM faculty to develop new research projects related to the UM Pepper Center’s research focus. The UM Pepper Center has in place a well-established leadership and administrative structure, a REC, a PESC, and four RCs: the Human Subjects and Assessment Core (HSAC); the Biomechanics Core (BC); the Design, Data and Biostatistics Core (DDBC); and the Core Facility for Aged Rodents (CFAR). The REC features three central elements: 1) a competitive program to select 2 promising UM junior faculty per year to conduct research relevant to the UM Pepper Center’s research and guarantee 50% effort for research career development; 2) a nationally recognized research training program for junior faculty engaged in such research, and 3) a Mentorship Program that enhances opportunities for junior faculty members to work closely with one or more UM senior investigators. The PESC will fund 5 or more pilot projects per year by leveraging OAIC funding with multiple other UM institutional resources. The RC’s will support multiple externally funded projects, the Pepper Center pilot grants and REC junior faculty, and continue to develop and test new methods to be used in Pepper Center research.