Translational Research Training inCancer Etiology & Prevention

鉴于有能力进行全面研究的研究科学家严重短缺， 可以将基本知识从实验室转化为临床和社区环境， 改善癌症预防和控制，本研究培训计划的目的是提供 匹兹堡大学医学院跨学科研究和教学环境的综合培训 中心（UPMC）希尔曼癌症中心。学员将接受培训，了解环境保护的作用， 暴露和遗传及其他生理因素在癌症发展和进展中的作用， 人类该培训计划涉及在临床不同轨道的跨学科培训课程 试验研究、转化研究和基于人群的观察和干预研究 癌症研究学员将与经验丰富的导师在一个多学科的团队进行工作 从机制实验和人群观察研究到随机干预研究 测试化学和免疫预防剂对人类癌症保护的功效的研究。的 指导研究将提供直接的研究经验，研究设计，方法， 研究方案的制定、实施、数据收集、分析和解释以及手稿 准备和出版。学员还将学习如何将临床前实验性研究的发现转化为 和/或观察性研究纳入癌症预防的随机干预性研究。独特的训练 该计划将培养下一代科学家，他们可以领导前沿的转化研究， 癌症病因学和预防。 这项培训计划是23名导师的共同努力，他们正在进行积极的研究项目， 匹兹堡大学的独立研究基金。这些院系来自以下研究 癌症流行病学和预防计划;乳腺癌和卵巢癌计划;生物行为 肿瘤学项目;癌症免疫学项目;癌症治疗学项目;头颈癌 计划;肺癌计划;和分子和细胞癌症生物学计划在UPMC希尔曼 癌症，排名第一的综合癌症中心，2017年直接研究资金为9400万美元。学员 将获得前沿的转化研究培训和经验。 我们要求继续资助，以支持3博士后和一个预科每年5年。 我们最近关于申请人招聘、保留和培训经验的数据显示， 具有高学习成绩的候选人。此外，我们成功招收了三分之一来自 代表性不足的种族和民族群体。培训计划的进展和成功将 在培训后的10年中，继续跟踪以往受训人员的职业发展和研究活动。

Given the severe shortfall of research scientists who are capable of conducting comprehensive studies that can translate fundamental knowledge from the bench to the clinical and the community settings for the improvement of cancer prevention and control, the purpose of this research training program is to provide integrated training in an inter-disciplinary research and teaching setting at the University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center. Trainees will be trained in understanding the role of environmental exposures and genetic and other physiological factors in the development and progression of cancer in humans. The training program involves cross-disciplinary training courses in different tracks in the Clinical Trial Research, the Translational Research, and the Population-Based Observational and Interventional Research on cancer. Trainees will work with experienced mentors in a multiple disciplinary team conducting researches from mechanistic experiments and observational studies in populations to randomized intervention studies to test the efficacy of chemo- and immuno-preventive agents on cancer protection in humans. The mentored research will provide direct research experience to trainees in study design, methodological development, implementation of research protocol, data collection, analysis and interpretation, and manuscript preparation and publication. Trainees also will learn how to translate discoveries from pre-clinical experimental and/or observational studies into randomized interventional studies for cancer prevention. The unique training of this program will train next generation of scientists who can lead the cutting-edge translational research on cancer etiology and prevention. This training program is a joint effort of 23 preceptors who are conducting active research projects all with independent research funding in University of Pittsburgh. These faculties are from the following research programs: Cancer Epidemiology and Prevention Program; Breast and Ovarian Cancer Program; Biobehavioral Oncology Program; Cancer Immunology Program; Cancer Therapeutics Program; Head & Neck Cancer Program; Lung Cancer Program; and Molecular and Cellular Cancer Biology Program at the UPMC Hillman Cancer, a top-ranked Comprehensive Cancer Center with $94 million direct research funding in 2017. Trainees will receive cutting-edge translational research training and experience. We request continuing funding to support 3 postdoctorates and one predoctorate per year for 5 years. Our recent data on applicant recruitment, retention and training experience demonstrate a relatively large pool of candidates with high academic performance. In addition, we successfully enrolled one-third trainees from the underrepresented racial and ethnical groups. The progress and success of the training program will continue to track the career development and research activities of past trainees in the 10 years post-training.