NRSA Training Core

哈佛大学催化剂(HC)TL1培训计划提供组织、课程和智力 用于创建和指导从事以疾病为导向的学生和教师社区的基础设施 研究人类生物学原理并将其转化为临床医学。TL1提供跨学科的 将人类生物学和转化医学相结合的博士项目，为研究生提供终身培训 哈佛大学(HU)的理科研究生课程。在过去的九年里，TL1计划 为Leder人类生物学项目中一些最优秀的研究生提供了支持 (LHB计划)。TL1目前支持39名学生，整合在由78名学生组成的更大的社区中 LHB计划。TL1项目的学生来自哈佛大学的研究生项目， 包括生物和生物医学、神经科学、免疫学、系统生物学和化学 和化学生物学。TL1的两位联席主管，康妮·切普科博士和托马斯·米歇尔博士， 在基础、翻译和临床科学方面的广泛和互补的专业知识，以及 具有研究生培训项目领导力的经验。 展望未来，TL1将继续代表HC翻译员工队伍的关键组成部分 发展(见核心D.翻译工作)。TL1将扩展以纳入新的培训计划 团队科学、定量方法和生物信息学，以补充当前的计划，以准备 未来高效的生物医学研究队伍。每年TL1将选出7名新的一年级毕业生 学生们。TL1学生获得博士学位的平均时间为5.7年。获奖者将是 支持他们攻读博士的头两年，之后将由他们的博士导师提供支持 研究计划，或从机构基金或基金会。 TL1培训核心的目标是：(目标1)提供研究生课程，重点是 量化的基于团队的主动学习方法，将培训研究生在机制和 人类生物学和面向疾病的T0/T1发现的方法学，并为他们提供直接的临床 与病人和医生接触；(目标2)建立面向人类疾病的翻译环境 将临床医学与人类学生研究联系起来的HC课外活动的研究 生物学和转化医学；以及(目标3)培养多样化的学生和教职员工群体 将严格的方法应用于将基本发现转化为预防的共同目标， 人类疾病的诊断和治疗，同时也接触到更广泛的波士顿社区。 TL1将挑选并支持培养致力于人类生物学事业的最佳研究生 和转化医学，以及谁将从胡和其他地方的学科中受益并做出贡献。

The Harvard Catalyst (HC) TL1 Training Program provides the organizational, curricular, and intellectual infrastructure for creating and mentoring a community of students and faculty engaged in disease-oriented research and the translation of principles of human biology to clinical medicine. TL1 offers an interdisciplinary PhD program that integrates human biology and translational medicine training for graduate students in life sciences graduate programs across Harvard University (HU). For the past nine years, the TL1 Program has provided a cornerstone of support for some of the best graduate students in the Leder Human Biology Program (LHB Program). TL1 currently supports 39 students, integrated in the larger community of 78 students in the LHB program. Students in the TL1 program come from graduate programs across Harvard University, including Biological and Biomedical Sciences, Neurosciences, Immunology, Systems Biology, and Chemistry and Chemical Biology. The two TL1 Co-Leads, Connie Cepko, PhD, and Thomas Michel, MD, PhD, have extensive and complementary expertise in basic, translational, and clinical science, and longstanding experience in the leadership of graduate training programs. Going forward, TL1 will continue to represent a key component of the HC Translational Workforce Development (see Core D. Translational Endeavors). TL1 will expand to incorporate new training programs in team science, quantitative methods, and bioinformatics that complement current programs to prepare an effective biomedical research workforce of the future. Each year TL1 will select seven new first-year graduate students. The average time to obtaining the PhD degree for TL1 students is 5.7 years. Awardees will be supported for the first two years of their PhD studies, after which support will come from their PhD mentors' research program, or from institutional funds or foundations. The objectives of the TL1 Training Core are to: (Aim 1) Provide a graduate curriculum with a focus on quantitative team-based active learning methods that will train graduate students in the mechanisms and methodologies of human biology and disease-oriented T0/T1 discovery, and provide them with direct clinical contact with patients and physicians; (Aim 2) Establish a context for human disease-oriented translational research in paracurricular activities across HC that connect clinical medicine with student research in human biology and translational medicine; and (Aim 3) Nurture a diverse community of students and faculty with shared goals of applying rigorous methodologies to the translation of basic discoveries to prevention, diagnosis, and treatment of human disease, while also reaching out into the broader Boston community. TL1 will select and support the training of the best graduate students committed to careers in human biology and translational medicine, and who will benefit from and contribute to the discipline at HU and beyond.