Vitamin D fluctuations and the mucosal immune response

总结 维生素D补充剂被认为是有用的，在高剂量的预防和治疗 与SARS-CoV-2感染（即COVID-19）相关的严重疾病。维生素D的状况显示 在急性呼吸道感染患者中，不幸的是，目前还不清楚这些 关联是因果关系。目前，维生素D在肺中的作用机制还不清楚。 完全理解此外，没有数据表明维生素D或其活性形式 维生素D（1，25（OH）2D，1，25 D）可有效改善病毒感染后的结果。 补充维生素D的效果和时机将在宿主对SARS-CoV-2感染的抵抗力上进行测试 在小鼠和仓鼠中。维生素D调节免疫反应的基本机制 对于维生素D的安全和有效宣传至关重要 补充。需要了解维生素D在肺部作用的机制 提供负责任的指导，以确定是否安全和有效地补充个人与高 大量的维生素D，以保护免受COVID-19疾病。

SUMMARY Vitamin D supplements have been suggested as being useful in high doses for preventing and treating severe disease associated with SARS-CoV-2 infection (i.e. COVID-19). Vitamin D status has been shown to be low in patients with acute respiratory infections. Unfortunately, it is yet unclear whether those associations are causal. Currently, the mechanisms underlying the effects of vitamin D in the lung are not completely understood. In addition, there is not data that demonstrates that vitamin D or the active form of vitamin D (1,25(OH)2D, 1,25D) is effective for improving outcomes following a viral infection. The effects and timing of supplemental vitamin D will be tested on host resistance to SARS-CoV-2 infection in mice and hamsters. The basic mechanisms by which vitamin D regulates the immune response following a respiratory virus infection are critical for the safe and effective messaging for vitamin D supplementation. Understanding the mechanisms underlying the effects of vitamin D in the lung is needed to provide responsible guidance on whether it is safe and effective to supplement individuals with high amounts of vitamin D to protect from COVID-19 disease.