CSHL 2021 Mechanisms of Metabolic Signaling Conference

冷泉港实验室会议 代谢信号传导机制 2021年5月18日至22日 项目摘要 这项建议寻求支持的会议“机制的代谢信号”， 2021年5月18日至22日在冷泉港实验室举行。会议将聚集各国领导人 在该领域，与初级教师，博士后研究员和研究生一起，讨论 最新进展，我们的理解代谢调节及其作用，在正常 生理学以及从肥胖到癌症的各种疾病状态。 代谢过程是生命所必需的，并且在生物体与生物体之间非常相似 从细胞到细胞。在哺乳动物中，特定的细胞类型使用代谢途径， 以特殊的方式来执行其细胞特定的功能。此外， 某些细胞类型通过以下方式来维持多细胞生物体的代谢稳态 调节血液中激素和代谢物信使的水平。代谢 当这些过程失败时，就会导致肥胖和糖尿病等疾病。与此同时， 癌症越来越被认为是一种恶性细胞通过改变 它的燃料代谢和忽略代谢信号。 会议将涵盖广泛的主题，从代谢串扰， 基因组和表观基因组与器官间串扰和养分利用。此外一个 会议专门讨论该领域的新兴技术。每届会议将由一名 这一领域的顶尖科学家一组杰出的特邀嘉宾将作口头报告。 发言者以及从提交的摘要中选出的发言者。选定的发言者将包括 研究生、博士后研究员和初级教员，旨在最大限度地包容青年人， investigators.特别重要的是两个海报会议，许多与会者可以 在有利于非正式讨论的气氛中介绍他们的工作。会议将由 中等规模，我们预计约有250人参加，其中绝大多数将是 展示海报或演讲。如果COVID-19疫情仍在持续， 2021年春季，我们将计划将会议作为虚拟活动进行。CSHL已经开始非常 成功举办虚拟会议，例如虚拟胶质细胞会议吸引了1，125人参加 与会者。即使会议能够亲自举行，我们也会考虑举行虚拟的 观众在亲自出席的基础上分层。这一点很重要，因为旅行 在大流行之后，人们的担忧可能会持续一段时间， 未来，虚拟出席会议将有助于减少科学会议对 气候变化，并使世界各地的实验室能够更公平地参与。

Cold Spring Harbor Laboratory Conference on Mechanisms of Metabolic Signaling May 18 – 22, 2021 Project Summary This proposal seeks support for the meeting on “Mechanisms of Metabolic Signaling” to be held at Cold Spring Harbor Laboratory in May 18 - 22, 2021. The meeting will assemble leaders in the field, together with junior faculty, postdoctoral fellows and graduate students, to discuss the latest advances in our understanding of metabolic regulation and its role in normal physiology as well as a variety of disease states ranging from obesity to cancer. Metabolic processes are required for life, and are remarkably similar from organism to organism and from cell to cell. In mammals, specific cell types use metabolic pathways in highly specialized ways to conduct their cell-specific functions. Further, the specialized function of some cell types serves to maintain metabolic homeostasis of the, multicellular organism by regulating levels of hormone and metabolite messengers in the bloodstream. Metabolic diseases such as obesity and diabetes result when those processes fail. At the same time, cancer is increasingly recognized as a state whereby the malignant cell proliferates by altering its fuel metabolism and ignoring metabolic signals. The meeting will cover a broad spectrum of topics ranging from Metabolic Crosstalk with Genome and Epigenome to Interorgan Crosstalk and Nutrient Utilization. In addition, one session is dedicated to Emerging Technologies in the field. Each session will be chaired by a leading scientist in the field. Oral presentations will be given by a group of distinguished invited speakers as well as speakers selected from submitted abstracts. Selected speakers will include graduate students, postdoctoral fellows and junior faculty aiming for maximal inclusion of young investigators. Of special importance are the two poster sessions, where many participants can present their work in an atmosphere conducive to informal discussion. The meeting will be of moderate size, and we expect about 250 people to attend, the vast majority of whom will be presenting a poster or talk. In the event that the COVID19 pandemic situation is still ongoing in spring 2021, we will plan to run the meeting as a virtual event. CSHL has begun very successfully holding virtual meetings, with the virtual glia meeting for example attracting 1,125 attendees. Even if the meeting is able to be held in person, we will consider having a virtual audience layered on top of the in person attendance. This will be important both because travel concerns are likely to persist for some time after the pandemic, and because, looking to the future, virtual attendance at meetings will help to reduce the effects of scientific conferences on climate change and enable more equitable participation from labs around the world.