Developmental Neuroscience and Child Psychopathology

发育神经科学和精神病理学是一个快速发展的领域， 很大的潜力，告知精神疾病的因果途径和机制的理解。这 T32专注于这一领域，由吕比博士和巴奇博士共同领导（他们在以下方面拥有丰富的专业知识： 发展精神病理学和神经科学），并在第一轮资助中非常成功， 享有竞争激烈的国家申请人库，并成功地推出了所有的年轻科学家， 到目前为止，该计划已经完成。我们寻求更新和扩大这项培训补助金，增加新的专业知识 在更广泛的神经成像措施，以及新的教师导师与专业知识的神经影响， 肠道微生物组。从公共卫生的角度来看，在该领域注入新的研究科学家， 发展神经科学和精神病理学是一个高度优先事项。拟议的多学科培训 方法是由一个概念模型，检查情感，认知，行为，神经生物学和 从发展的角度看精神病理学的遗传和环境方面。此外，本次培训 该计划的指导思想是，认识到精神疾病的风险、发病和病程 是通过大脑发育过程的复杂相互作用而产生的，这些过程受到心理社会、遗传和 生物（包括肠道微生物）因素在子宫内开始相互作用，并持续整个 发展圣路易斯华盛顿大学（WUSTL）的许多调查人员都有丰富的记录 在儿童神经影像学和相关方法的许多方面的经验，包括对结构和 功能磁共振方法在非常早期的儿童，诱发反应电位（ERP）， 高密度扩散光学层析成像（HD-DOT）。此外，WUSTL在以下方面享有国际声誉： 精神病遗传学和肠道微生物组的工作，许多研究人员谁可以带来行为和 分子遗传学的方法，以了解神经生物学的发展精神病理学。 该计划的导师有丰富的数据库来源于纵向研究，几个 这种疾病始于儿童早期和子宫内。该计划的导师提供了一个独特的多学科培训 环境中，追求这个令人兴奋的领域集中在童年，鉴于既定的合作 在WUSTL医学院临床和基础部门的儿童研究人员之间， WUSTL的神经科学和神经影像学项目一直处于发展的前沿， 认知和情感神经科学。此外，基础和临床研究人员之间的互动 发展神经科学提供了一个持续的机会，帮助培养下一代的年轻科学家 谁能从核心的角度来探讨精神病理学的发展病因学问题， 人类行为的心理和神经机制，可以告知和跨越传统的界限， 精神病理学，NIMH研究领域标准倡议（RDOC）的核心方法。

Developmental neuroscience and psychopathology is a rapidly growing domain with established success and great potential to inform the understanding of the causal pathways and mechanisms of mental illness. This T32, which is focused on this domain, is co-led by Drs. Luby and Barch (with complimentary expertise in developmental psychopathology and neuroscience), and has been very successful in the first cycle of funding, enjoying a highly competitive national applicant pool and successfully launching all of the young scientists who have completed the program thus far. We seek to renew and expand this training grant, adding new expertise in a wider range of neuroimaging measures, as well as new faculty mentors with expertise in the neural effects of the gut microbiome. From a public health perspective, an infusion of new research scientists in the area of developmental neuroscience and psychopathology is a high priority. The proposed multi-disciplinary training approach is guided by a conceptual model that examines emotional, cognitive, behavioral, neurobiological and genetic and environmental aspects of psychopathology from a developmental perspective. Further, this training program is guided by a perspective that recognizes that the risk, onset, and course of psychiatric disorders arises through a complex interplay of brain developmental processes influenced by psychosocial, genetic, and biological (including gut microbial) factors that interact beginning in utero and continue throughout development. Numerous investigators at Washington University in St. Louis (WUSTL) have a rich track record of experience in many aspects of child neuroimaging and related methods, including a focus on structural and functional magnetic resonance approaches in very early childhood, evoked response potentials (ERP) and high density diffuse optical tomography (HD-DOT). Further, WUSTL has an international reputation in psychiatric genetics and gut microbiome work, with many investigators who can bring both behavioral and molecular genetic approaches to bear on understanding the neurobiology of developmental psychopathology. The program mentors have a rich body of available databases derived from longitudinal studies, several of which began in early childhood and in utero. The program mentors provide a unique multidisciplinary training environment in which to pursue this exciting domain focused on childhood, given the established collaborations between child researchers in the WUSTL School of Medicine clinical and basic departments, and the state of the program in neuroscience and neuroimaging at WUSTL that has been at the forefront of developmental cognitive and affective neuroscience. Further, interactions between researchers in basic and clinical developmental neuroscience offer an ongoing opportunity to help train the next generation of young scientists who can pursue questions about the developmental etiology of psychopathology from the perspective of core psychological and neural mechanisms of human behavior that can inform and span traditional boundaries of psychopathology, an approach central to the NIMH Research Domain Criteria Initiative (RDOC).