Renewal of Delaware Center for Neuroscience Research

摘要 特拉华州神经科学研究中心，成立于2012年，第一阶段为Cobre 该奖项是特拉华州立大学和特拉华大学之间的合作项目。 它独特地将来自两个非常不同的机构的教师和研究资源聚集在一起：a 为少数族裔服务的本科大学，在神经科学研究(DSU)方面具有新兴实力， 以及该州的旗舰研究型大学(UD)。科布雷项目第一阶段的重点是 支持一组早期调查人员的研究和专业发展，包括 在科布雷的支持下受聘于DSU的项目负责人、试点资助PI和新教师，以及 帮助调查人员取得成功和科学成熟。这个节目已经非常精彩了 科布雷资助的研究人员成功发表了70多篇论文，三名项目负责人“毕业” 进入R01 Support，一名试点调查员毕业于NSF职业奖项，两名新教员 在科布雷的支持下被招募到特斯拉州立大学，获得K01奖项。我们的第二阶段项目将加强这两个方面 我们的中心和特拉华州的神经科学研究通过催化机构对研究的投资 基础设施，并继续增加R01-竞争性神经科学研究人员的数量。 在我们进入第二阶段时，为了支持我们的Cobre努力，UD在 购买一台具有地图绘制功能的3T磁共振扫描仪，为神经科学提供研究基础设施 人类大脑活动，以及生物医学和脑成像中心的建立。我们的阶段 Cobre II奖将催化购买7T小孔磁铁的额外投资，以 扩展CBBI的功能，将啮齿动物模型的磁共振成像包括在内。 我们神经科学中心的首要科学目标是团结和支持 神经学家在多个尺度上工作，从人类受试者到啮齿动物和无脊椎动物模型，再到 提高我们对大脑动态功能的理解。在第二阶段，我们将开展三项工作 我们中心的具体目标：1)通过以下方式加强特拉华州的研究基础设施和能力 充分发展生物医学和脑成像中心，包括仪器和专业知识 2)进一步发展跨学科、跨机构的特拉华中心 神经科学研究作为一个支持性的科学社区，专注于研究动态结构- 大脑中的功能关系；以及3)让一组新的研究人员参与中心的 集成的指导和专业发展计划，帮助初级教师成为 独立的、外部资助的研究人员。继续这个科布雷计划将有两个重要的 长期利益。首先，我们将继续前进到我们的特拉华州神经科学研究中心 成为一个自给自足、具有竞争力的研究中心，这将促进我们对大脑的理解 并增加在特拉华州进行的多学科生物医学和行为研究的数量。 其次，该中心将支持一批早期教师成为R01资助的研究人员和 在学术上和科学上都能晋升到高级水平。

Summary The Delaware Center for Neuroscience Research, established in 2012 with a phase I COBRE award, is a collaboration between Delaware State University (DSU) and the University of Delaware (UD) that uniquely brings together faculty and research resources from two very different institutions: a minority-serving, undergraduate university with an emerging strength in neuroscience research (DSU), and the state's flagship research university (UD). Phase I of the COBRE project was focused on supporting the research and professional development of a group of early stage investigators that included Project Leads, Pilot Grant PIs, and new faculty who were hired at DSU with COBRE support, and helping the investigators achieve grant success and scientific maturity. The program has been very successful with over 70 publications by COBRE-supported researchers, three Project Leads “graduated” into R01 support, a pilot investigator graduated to an NSF CAREER award, and two of the new faculty recruited to DSU with COBRE support winning K01 awards. Our phase II project will strengthen both our Center and neuroscience research in Delaware by catalyzing institutional investment in research infrastructure and continuing to grow the number of R01-competitive neuroscience researchers. Supporting our COBRE effort as we move to Phase II, UD has made a significant investment in the research infrastructure for neuroscience with the purchase of a 3T MRI scanner with the capability to map human brain activity, and the establishment of the Center for Biomedical and Brain Imaging. Our phase COBRE II award will catalyze additional investment in the purchase of a 7T, small bore magnet to expand the capabilities of the CBBI to include magnetic resonance imaging of rodent models. The overarching scientific goal of our Neuroscience Center is to bring together and support neuroscientists working at multiple scales, from human subjects to rodent and invertebrate models to improve our understanding of the dynamic function of the brain. During Phase II we will pursue three specific aims for our Center: 1) strengthening the research infrastructure and capacity in Delaware by fully developing the Center for Biomedical and Brain Imaging to include instrumentation and expertise for small animal MRI; 2) to further develop the interdisciplinary, inter-institutional Delaware Center for Neuroscience Research as a supportive scientific community focused on investigating dynamic structure- function relationships in the brain; and 3) to involve a new group of investigators in the Center's integrated mentoring and professional development program that helps junior faculty become independent, externally-funded researchers. Continuing this COBRE program will have two significant long-term benefits. First, we will continue to advance to our Delaware Center of Neuroscience Research to be a self-sustaining, and competitive research center that will advance our understanding of the brain and increase the amount of multidisciplinary biomedical and behavioral research carried out in Delaware. Second, the Center will support a group of early-stage faculty to become R01-funded investigators and advance to senior levels both academically and scientifically.