Child Health ResearcH Career Development Award (CHRCDA) Program (K12)

项目摘要 波士顿儿童医院CHRCDA计划的目标是培养儿科医生， 他们正在进行世界级的研究， 世界我们的学者将在该项目下进行基于实验室的基础和转化研究 指导儿童医院和其他哈佛附属医院的杰出科学家， 哈佛医学院。我们的计划已经建立，以确保独立的发展， 科学家在这个建议中，我们描述了一个计划，包括密集的指导，一个全面的教学， 计划，一个计划，以确保科学发展的学者。方案监督将是 由外部现场访问委员会和内部指导委员会提供。计划已经就绪， 项目自我评估和学术进展的审查。 我们建议继续为三个学者职位提供资金。奖学金将资助至少两个 该计划将持续两年，进一步的资金将取决于进展情况和奖学金候选人的总体情况。学者们将 教师最经常在讲师的职级，但助理教授谁是早期的 发展独立事业的人士亦有资格申请。学者将被视为在任何 从他们的指导开始到他们被认为是两年的时间点 从提交他们的第一个R级NIH赠款或同等，虽然不超过四年结束后， 奖学金培训。 学者们将从事广泛的科学研究。过去和现在的学者在 如核重编程机制、疟疾抗原的结构生物学、免疫学等领域。 对肿瘤的反应，癌症治疗，免疫缺陷的分子基础，宿主-微生物组相互作用， 肺和肠干细胞，链球菌感染的分子病理学，性功能障碍， 分化这些研究将阐明基本的分子机制，并将导致 在儿科疾病的所有领域开发新的治疗方式，包括血液学/肿瘤学， 内分泌学、肾脏学、传染病学、免疫学、肺病学和神经学。 !

Project Summary The goal of the Boston Children's Hospital CHRCDA Program is to develop pediatrician physician-scientists who are performing world-class research that will improve health care for children in this country and around the world. Our Scholars will be performing laboratory-based basic and translational research under the mentorship of outstanding scientists at Children's Hospital and other Harvard Associated Hospitals and Harvard Medical School. Our program has been established to ensure the development of independent scientists. In this proposal we describe a program that includes intensive mentoring, a comprehensive didactic program, and a program to ensure the scientific development of Scholars. Programmatic oversight will be provided by an External Site Visit Committee and an Internal Steering Committee. Plans are in place for programmatic self-evaluation and for review of Scholar Progress. We propose to continue the funding of three Scholar positions. Scholars will be funded for a minimum of two years, with further funding contingent on progress and the overall pool of Scholar candidates. Scholars will be faculty members most often at the rank of Instructor, but Assistant Professors who are early in the development of their independent careers will also be eligible to apply. Scholars will be considered at any point from the beginning of their Instructorship to the point where they are considered to be two years away from submitting their first R-level NIH grant or equivalent, though no more than four years beyond the end of fellowship training. Scholars will work in a broad range of scientific investigations. Past and present Scholars have worked in areas such as the mechanism of nuclear reprogramming, structural biology of malaria antigens, immune response to tumors, cancer therapeutics, molecular bases for immunodeficiency, host-microbiome interactions, lung and intestinal stem cells, molecular pathology of streptococcal infection, and disorders of sexual differentiation. These investigations will elucidate fundamental molecular mechanisms and will lead to the development of new therapeutic modalities in all areas of pediatric disease, including hematology/oncology, endocrinology, nephrology, infectious disease, immunology, pulmonology and neurology. !