Identification of Remediation Technologies and Conditions that Minimize Formation of Hazardous PAH Breakdown Products at Superfund Sites

项目概要- SIMONICH/SEMPRINI项目 尽管由NIEHS超级基金研究计划资助的补救和检测研究项目 节省了超过1亿美元，我们实验室和其他机构最近的研究表明， 生物和非生物修复后污染土壤和沉积物增加， 转化产物仅占毒性增加的23-28%。极性继发性PAH 转化产物（例如，环氧化物、羰基化合物和开环产物）可能占大多数 修复后毒性增加。本项目的首要目标是学习如何识别补救措施 最大限度地减少有害PAH分解产物形成的技术。我们的首要目标是 通过计算模型预测，多环芳烃的二次转化产物，将形成在 生物（微生物）和非生物（加热或就地化学氧化）补救。我们的第二个具体目标是 测量在实验室规模的生物和非生物过程中形成的二次PAH转化产物， 修复实验我们将把我们的数据反馈到Aim 1中，以改进我们的计算模型。我们的第三 具体目标是测量现实世界超级基金土壤中多环芳烃的二次转化产物， 修复前后以及自然衰减后的沉积物。我们的第四个具体目标是： 确定补救技术，或补救技术的组合，以尽量减少形成 有毒的初级和次级转化产物的多环芳烃和B），以了解如何最佳 补救策略取决于补救条件以及土壤和沉积物的性质。 我们还计划测试任何新的补救技术，我们的利益相关者，或其他SRP中心，希望 评估。我们将应用被动采样装置评估多环芳烃的生物有效性及其转化 产品.我们还应用土柱沥滤技术来评估它们从土壤中沥滤到 地下水这四个具体目标将有助于我们回答利益相关者的问题 关于超级基金场地的哪些PAH转化产品是危险的， 产品有可能导致人类接触，哪些接触有可能 危害人类健康。根据我们的调查结果，我们将向特定超级基金地点的经理提供建议 关于哪些补救战略（或战略组合）最大限度地减少对社会的威胁。

PROJECT SUMMARY – SIMONICH/SEMPRINI PROJECT Although remediation and detection research projects funded by the NIEHS Superfund Research Program have saved >$100 million, recent studies by our laboratory and others have shown that the toxicity of PAH- contaminated soils and sediments increases after biotic and abiotic remediation and that PAH primary transformation products can account for only 23-28% of the increased toxicity. Polar secondary PAH transformation products (e.g., epoxides, carbonyls, and ring-cleavage products) likely account for the majority of toxicity increase after remediation. The overarching goal of this project is to learn to identify remediation technologies that minimize formation of hazardous PAH breakdown products. Our first specific aim is to predict, via computational modeling, the secondary transformation products of PAHs that will form during biotic (microbial) and abiotic (with heat or in situ chemical oxidation) remediation. Our second specific aim is to measure the secondary PAH transformation products that form during laboratory-scale biotic and abiotic remediation experiments. We will feed back our data into Aim 1 to refine our computational model. Our third specific aim is to measure the secondary transformation products of PAHs in real-world Superfund soils and sediments before and after remediation, as well as after natural attenuation. Our fourth specific aim is a) to identify remediation technologies, or combinations of remediation technologies, that minimize the formation of toxic primary and secondary transformation products of PAHs and b) to understand how the optimal remediation strategy depends on the remediation conditions and on the properties of the soils and sediments. We also plan to test any new remediation technologies our stakeholders, or other SRP Centers, wish to evaluate. We will apply passive sampling devices to assess the bioavailability of PAHs and their transformation products. We also apply soil column leaching techniques to assess their tendency to leach from to soil to groundwater. These four Specific Aims, taken together, will help us answer our stakeholders' questions regarding which PAH-transformation products at Superfund sites are hazardous, which transformation products have the potential to result in human exposure, and which exposures have the potential to compromise human health. Based on our findings, we will advise the managers of specific Superfund sites regarding which remediation strategies (or combinations of strategies) minimize the threat to society.