癌症中心支持补助金-猫眼课题宝

癌症中心支持补助金

批准号：

10455154

负责人：

H. Shelton Earp

金额：

$24.99万

依托单位：

UNIV OF NORTH CAROLINA CHAPEL HILL

依托单位国家：

美国

项目类别：

财政年份：

1997

资助国家：

美国

项目状态：

未结题

起止时间：

1997-06-01 至 2025-11-30

来源：

https://reporter.nih.gov/project-details/10455154

关键词：

Appointment Arts Award Basic Cancer Research Basic Science Behavioral Bioinformatics Biology Budgets Cancer Burden Cancer Center Cancer Center Support Grant Cancer Control Caregivers Caring Catchment Area Chemicals Clinic Clinical Data Clinical Protocols Clinical Research Clinical Sciences Clinical Trials Communication Communities Community Outreach Comprehensive Cancer Center Consultations Data Development Direct Costs Discipline of Nursing Disease Early Diagnosis Education and Outreach Epidemiology Epigenetic Process Evaluation Research Facility Construction Faculty Fostering Funding Future Gap Junctions Genetic Research Genomic approach Government Grant Health Health Resources Health Services Healthcare Human Incidence Information Systems Infrastructure Insurance Carriers Intervention Intervention Trial Investments Leadership Malignant Neoplasms Measures Medicaid Medicare Minority Groups Mission Molecular Epidemiology Monitor Morbidity - disease rate Names North Carolina Oncology Outcome Patient Care Patients Performance Pharmacologic Substance Pharmacy facility Policies Population Population Heterogeneity Population Sciences Prevention Privatization Productivity Protocols documentation Public Health Publications Publishing Research Research Personnel Resource Sharing Resources Role Rural Population Schools Science Scientist Services Stretching System Talents Technology The Cancer Genome Atlas Therapeutic Time Training Training and Education Translating Translations United States Universities Urban Population anticancer research authority base cancer care cancer genetics cancer health disparity cancer research center director cancer therapy career college community based participatory research community college community engagement data management drug discovery epidemiology study imaging detection innovation malignant breast neoplasm medical schools member minority disparity mortality multidisciplinary neoplasm registry operation population based population health programs public policy on tobacco recruit safety net screening services senior faculty survivorship undergraduate student

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中文摘要

翻译

卡波西肉瘤（KS）是一种与卡波西肉瘤相关疱疹病毒（KSHV）相关的人类恶性肿瘤。KS仍然是世界范围内最常见的hiv相关癌症。KS病变的特征是内皮源性梭形细胞增生、血管渗漏和炎症性白细胞浸润。在这些病变中，炎性白细胞分泌kshv感染细胞赖以生长和存活的细胞因子和生长因子。感染kshv的内皮细胞通过调节其表面粘附因子的表达促进炎症细胞的浸润。我们发现KSHV感染诱导了新型内皮粘附因子的表达，增加了白细胞的粘附和跨内皮迁移。我们建议确定KSHV诱导白细胞粘附和跨内皮迁移的机制，并利用艾滋病和癌症标本资源（ACSR）的组织标本验证这一过程的生物学特性。我们的建议还将确定hiv感染个体治疗KS的新靶点。

英文摘要

Kaposi’s sarcoma (KS) is a human malignancy associated with Kaposi’s sarcoma-associated herpesvirus (KSHV). KS continue to be the most common HIV-associated cancer world-wide. KS lesions are characterized by proliferating endothelial-derived spindle cells, leaky blood vessels, and inflammatory infiltrating leukocytes. Within these lesions, inflammatory leukocytes secret cytokines and growth factors that KSHV-infected cells rely on for growth and survival. KSHVinfected endothelial cells promote the infiltration of inflammatory cells by modulating the expression of adhesion factors on its surface. We have found that KSHV infection induces the expression of novel endothelial adhesion factors and increases leukocyte adhesion and transendothelial migration. We propose to determine the mechanism by which KSHV induces leukocyte adhesion and transendothelial migration and validate the biology of this process using tissue specimens from the AIDS and Cancer Specimen Resource (ACSR). Our proposal will also identify new targets for therapies against KS in HIV-infection individuals.

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