Rapid Quantitative Assessment of Knee Joint with Compressed Sensing

项目摘要 骨关节炎（OA）是一种退行性关节疾病，在美国影响超过2700万人 一个人这一庞大的受影响人群和随之而来的严重的OA衰弱导致了巨大的费用， 医疗保健系统。OA的特征在于生物化学、结构和形态降解， 关节软骨的细胞外基质（ECM）成分。ECM主要由两部分组成 包括蛋白聚糖（PG）和胶原纤维的大分子组。软骨的早期诊断 退变需要能够非侵入性地检测PG浓度和胶原蛋白的变化 在形态发生变化之前的完整性。T1ρ和T2弛豫时间受这些病理性 是全世界使用最广泛的生化软骨MRI序列。. 该提案的总体目标是开发、优化和转换高空间分辨率的3D各向同性 MRI序列（700µmX700µmX700µm），用于同时评估形态测量和双指数3D- T1ρ（T2）标测序列（每个方案均在10分钟内），用于改善 软骨的形态学（软骨厚度和体积）和生化表征 临床3 T扫描仪采用压缩感知（CS）和并行成像（PI）的组合。的 提出的加速、各向同性、高空间分辨率、多分量3D-T1ρ（T2）映射技术可以 易于纳入软骨生化评估的常规临床方案， 标准的形态学评价，并可作为未来的成像生物标志物，用于疾病的修改 治疗OA。这项拟议研究的结果将显著影响我们的个性化能力， 治疗方案，并可能防止过早OA的发展。

PROJECT SUMMARY Osteoarthritis (OA) is a degenerative joint disease, affecting more than 27 million people in the United States alone. This large affected population and the severe consequent debility of OA lead to significant expenses to the health care system. OA is characterized by biochemical, structural and morphologic degradation of components of the extracellular matrix (ECM) of articular cartilage. The ECM is composed of primarily two groups of macromolecules including proteoglycan (PG) and collagen fibers. Early diagnosis of cartilage degeneration would require the ability to non-invasively detect changes in PG concentration and collagen integrity before morphological changes occur. T1ρ and T2 relaxation times are affected by these pathological processes and are the most widely used biochemical cartilage MRI sequences worldwide. . The overarching goal of this proposal is to develop, optimize, and translate high spatial resolution 3D-isotropic- MRI sequence (700µmX700µmX700µm) for simultaneous assessment of morphometry and biexponential 3D- T1ρ (T2) mapping sequences (each protocol under 10 minutes) for improved quantitative assessment of morphological (cartilage thickness and volume) and biochemical characterization of cartilage on a standard clinical 3T scanner employing combinations of compressed sensing (CS) and parallel imaging (PI). The proposed accelerated, isotropic, high spatial resolution, multicomponent 3D-T1ρ (T2) mapping techniques can be easily incorporated into routine clinical protocols for biochemical assessment of cartilage in addition to standard morphological evaluation and could serve as future imaging biomarkers for disease modifying therapies for OA. The outcome of this proposed study will significantly impact our ability for personalized treatment regimens and possibly prevent the development of premature OA.