Integrated Musculoskeletal Training Program

项目总结 肌肉骨骼疾病和损伤，如骨关节炎、骨质疏松症、肌腱病、 椎间盘退变和更多的椎间盘退变仍然是导致残疾的主要原因 在世界范围内，这给医疗保健系统带来了巨大的社会经济负担 国家。这个时代还带来了组织和组织领域的范式转变的科学革命 再生医学，体内和体外疾病建模，测序和基因组学，高 分辨率成像和生物力学。替补席上的这些发展需要 科学、工程和医学方面的多学科专业知识，以继续加快 肌肉骨骼研究的发展轨迹，最终解决床边未得到满足的临床需求。 然而，肌肉骨骼研究的研究培训仍然在很大程度上被孤立在单一的 学科方法和设置。在此应用程序中，我们提出了一种新的集成 肌肉骨骼训练计划(IMTP)汇集了世界领先的肌肉骨骼 哥伦比亚大学具有生物医学工程专业知识的研究人员和临床医生 以及分子生物学、病理学和细胞生物学、机械工程和创新。这 独特的博士前培训计划侧重于整合所需的多个学科 对该领域的下一代科学家和工程师进行前沿研究培训。这个 拟议的T32培训计划将在肌肉骨骼领域建立独特的培训模式 具有下列必要培训内容的疾病：(1)肌肉骨骼临床指导 医学(整形外科、物理医学和康复、风湿病、放射学、 等)，(2)由生物工程师、生物学家和临床医生组成的团队强制共同建议， (3)创新和设计培训，以确定临床需求和知识差距/ 技术，以及(4)多样性和公平挑战方面的培训。这项T32培训计划将 为促进、加强和深化多学科提供独特和及时的机会 通过为学员提供进入所需技能和价值观的支持来进行肌肉骨骼研究 生物医学研究队伍和解决肌肉骨骼疾病的复杂问题 在未来。

PROJECT SUMMARY Musculoskeletal diseases and injuries such as osteoarthritis, osteoporosis, tendinopathy, intervertebral disc degeneration and many more continue to be the leading causes of disability worldwide, imposing an enormous socioeconomic burden on the health care system in this country. This era has also ushered in paradigm-shifting scientific revolutions in tissue and regenerative medicine, in vivo and ex vivo disease modeling, sequencing and genomics, high- resolution imaging and biomechanics. These developments at the bench side require multidisciplinary expertise in science, engineering, and medicine to continue to accelerate the trajectory of musculoskeletal research to ultimately address unmet clinical needs at the bedside. However, research training in musculoskeletal research continues to be largely siloed into single discipline approaches and settings. In this application, we propose a new Integrated Musculoskeletal Training Program (IMTP) that brings together world leading musculoskeletal researchers and clinicians at Columbia University with expertise in biomedical engineering, cell and molecular biology, pathology and cell biology, mechanical engineering and innovation. This unique predoctoral training program focuses on integrating the multiple disciplines required for cutting edge research training of the next generation of scientists and engineers in the field. The proposed T32 training program will establish a unique training paradigm in musculoskeletal disease, with the following required training elements: (1) clinical preceptorship in musculoskeletal medicine (orthopaedic surgery, physical medicine and rehabilitation, rheumatology, radiology, etc.), (2) mandatory co-advising by a team consisting of a bioengineer, biologist, and a clinician, (3) innovation and design training for identifying clinical needs and gaps in knowledge / technology, and (4) training in diversity and equity challenges. This T32 training program will provide a unique and timely opportunity to promote, enhance, and deepen multidisciplinary musculoskeletal research by supporting trainees with the skills and the values needed to enter the biomedical research workforce and to solve the complex problems of musculoskeletal disease in the future.