Mid-Career Development and Mentoring on Financial Vulnerability and Alzheimer's Disease

项目总结/摘要 了解老年人的经济剥削是一个重要的公共卫生问题;然而， 人们对一些老年人可能更容易受到欺诈的原因知之甚少。为了解决这个问题，我 已经制定了一项研究计划，重点是了解不同的行为，背景， 影响老年人金融决策和金融剥削脆弱性的神经生物学因素 年龄这项研究计划利用了由外资助的南加州大学资源和合作 与拉什阿尔茨海默病中心（RADC）的努力，共同为学员提供机会， 与不同的数据集和研究导师合作。认知能力下降， 财务决策被认为是老年人欺诈的一个主要风险因素。老年痴呆症患者 疾病及相关性痴呆（ADRD）和轻度认知障碍（MCI）被认为是最危险的 进行经济剥削然而，大多数研究都是基于间接或轶事证据。 与此相关的是，那些经历骗局和欺诈的ADRD患者的认知症状特征尚不清楚。 神经影像学工作暗示了特定脑区的结构和连接， 机制;然而，这些尚未具体涉及ADRD患者。重要的是，由于 与阿尔茨海默病相关的风险因种族而异，金融欺诈率似乎也有所不同。 根据种族，理解这些差异在科学上是至关重要的。为了解决这些问题， K24职业发展奖的研究项目建议扩大现有的 通过调查健康和退休领域的金融欺诈与ADRD之间的关联， 研究（HRS）和拉什阿尔茨海默病中心（RADC）队列。HRS被认为是最大的 也是美国最具全国代表性的老龄化研究。2016年，HRS启动了模块2， 在调查中引入了财务欺诈项目。自2013年以来，RADC收集了财务决策 制作和神经影像学数据作为其大型的、以社区为基础的、神经流行病学的 研究衰老，我一直是其中许多研究的积极合作者。拟议的指导小组 由南加州大学和RADC教师组成的团队将为我和我的学员提供指导， 发展，以及HRS和RADC队列的当前研究方法。最后，由于金融 最近，非痴呆老年人的脆弱性与阿尔茨海默氏症的更大风险有关 在纵向模型中，我们的第二个目标是探索临床前阿尔茨海默病的关联 疾病血液生物标志物与当地老年人亚组的经济剥削风险， 认知障碍这一职业中期奖励将解决ADRD的财务脆弱性问题。

PROJECT SUMMARY/ABSTRACT Understanding financial exploitation among older adults is an important public health issue; however, the reasons why some older adults may be more susceptible to fraud are poorly understood. To address this, I have developed a program of research focused on understanding the diverse behavioral, contextual, and neurobiological factors that impact financial decision making and financial exploitation vulnerability in older age. This program of research leverages extramurally-funded USC-based resources and collaborative endeavors with the Rush Alzheimer’s Disease Center (RADC), which together provide trainees the opportunity to work with diverse datasets and research mentors. Age-related decline in cognitive abilities impacting financial decision making is believed to be a central risk factor for fraud in older age. Those with Alzheimer’s Disease and Related Dementias (ADRD) and Mild Cognitive Impairment (MCI) are believed to be most at risk for financial exploitation. However, most of this research is based either on indirect or anecdotal evidence. Relatedly, cognitive symptom profiles of those with ADRD who experience scam and fraud are unknown. Neuroimaging work has implicated the structure and connectivity of specific brain regions as neurobiological mechanisms; however, these have yet to be implicated in ADRD patients specifically. Importantly, since factors associated with Alzheimer’s Disease are known to differ by race, and rates of financial fraud appear to differ according to race, an understanding of these differences is a scientifically crucial. To address these questions, the research project for this K24 Career Development Award proposes to expand the current program of research by investigating the associations between financial fraud and ADRD in the Health and Retirement Study (HRS) and the Rush Alzheimer’s Disease Center (RADC) cohorts. The HRS is considered the largest and most nationally-representative study of aging in the United States. In 2016, the HRS initiated Module 2, which introduced financial fraud items into the survey. Since 2013, the RADC has collected financial decision making and neuroimaging data as an integrated part of their large, community-based, neuroepidemiologic studies of aging, and I have been an active collaborator on many of these studies. A proposed mentoring team consisting of USC and RADC faculty will provide me and my mentees guidance in mentorship, professional development, and current research approaches in the HRS and RADC cohorts. Finally, because financial vulnerability in non-demented older adults has recently been associated with greater risk for Alzheimer’s Disease in longitudinal models, we secondarily aim to explore the association of preclinical Alzheimer’s Disease blood-based biomarkers with financial exploitation risk in a subset of local older adults without cognitive impairment. This mid-career award will address financial vulnerability considerations in ADRD.