Center on Emerging and Zoonotic Infectious Diseases

总体项目摘要： 这个COBRE应用程序将形成一个独特的新兴和人畜共患传染病研究中心 （EZID）.四个主要的研究项目桥梁在传染病计划的卓越领域， 堪萨斯州立大学（KSU）的文理学院和兽医学院。的 项目研究各种病原体的毒力因子和宿主-病原体相互作用，利用基础和 在体外系统和动物模型中的翻译方法。EZID中心的首要目标是 促进我们对堪萨斯州新出现的人畜共患传染病的了解。我们的目标是 这也与NIH的战略计划“将发现转化为健康”保持一致。两个研究核心设施将 支持研究项目和计划，动物模型/病理学核心和分子和细胞 生物学核心，在KSU和堪萨斯州提供独特的研究基础设施资源。的 EZID的成功和成长将通过各种计划实现：（1）教师指导计划， 将由国内/国际公认的导师提供出色的指导。指导团队将 实施个性化的发展计划，并支持研究计划和赠款申请的各个方面 流程，以确保R 01级的资金由项目负责人;（2）在KSU新的教师招聘，以确保 EZID的增长和可持续性，以及核心设施的生产性使用;（3）试点和种子赠款 通过资助堪萨斯州内大学的项目来促进中心发展的计划;以及（4） 一个区域科学网络（RSN），将提供跨学科和机构间的合作， 更多地利用核心设施，并获得更多的核心设施和培训机会。初始 RSN的合作伙伴包括堪萨斯州和内布拉斯加州的几个COBREs，以及K-INBRE 堪萨斯大学医学院的中心。该RSN将增长和扩大到其他大学， 该地区以及在同一使命空间工作的国家COBRE中心，从而提供机会 研究项目的快速增长。这些EZID计划将成为研究生产力的基础。 得到支持和支持，有助于推进COBRE核心项目的整体成功和声誉， 试点项目，博士后和研究生学员，以及相关的EZID教师。EZID中心将 举办年度研究研讨会，将包括来自EZID项目和RSN成员的参与者， 并与网络内外的调查人员分享研究成果，促进国家和 EZID的国际声誉。

Overall Project Summary: This COBRE application will form a unique research center on Emerging and Zoonotic Infectious Diseases (EZID). Four primary research projects bridge areas of excellence in the Infectious Diseases programs at Kansas State University (KSU) within the Colleges of Arts and Sciences and Veterinary Medicine. The projects examine virulence factors and host-pathogen interactions of various pathogens, utilizing both basic and translational approaches in in vitro systems and in animal models. The overarching goal of the EZID center is to advance our understanding of emerging and zoonotic infectious diseases in the State of Kansas. Our goals are also clearly aligned with NIH's strategic plan “Turning Discovery into Health”. Two research core facilities will support the research projects and programs, an Animal Model/Pathology Core and a Molecular and Cellular Biology Core, offering unique research infrastructure resources within KSU and the State of Kansas. The success and growth of EZID will be enabled through various programs: (1) a faculty mentoring program that will provide outstanding mentoring by nationally/internationally recognized mentors. The mentoring team will implement individualized development plans, and support all aspects of research programs and grant application processes to secure R01-level funding by the project leaders; (2) new faculty recruitment at KSU to ensure the growth and sustainability of EZID, as well as productive use of core facilities; (3) a pilot and seed grant program that will promote center growth by funding projects at universities within the State of Kansas; and (4) a regional scientific network (RSN) that will provide inter-disciplinary and inter-institutional collaborations, increased usage of core facilities, and access to additional core facilities and training opportunities. Initial partners of the RSN include several COBREs within the State of Kansas and Nebraska, as well as the K-INBRE center at the University of Kansas Medical School. The RSN will grow and expand both to other universities in the region and to national COBRE centers working in the same mission space, thereby providing opportunities for the rapid growth of research programs. These EZID programs will be the basis by which research productivity is enabled and supported, helping to advance the overall success and reputation of the COBRE core projects, pilot projects, post-doctoral and graduate student trainees, and associated EZID faculty. The EZID center will host annual research symposia that will include participants from EZID projects and RSN members to showcase and share research with investigators from inside and outside of the network, promoting the national and international reputation of EZID.