Advanced Development of Vaccines for Infectious Diseases

该项目的主要目标是支持候选产品的先进开发，以便在故意释放或应对自然发生的传染病爆发后的事件环境中使用。该合同可能支持单个疫苗成分的配方和生产，以及稳定性测试、非临床免疫原性和非人类灵长类动物的有效性测试、允许GLP重复剂量毒理学的IND、IND的提交和最终的临床评估。

The primary objective of this project is to support the advanced development of candidate products for use in post-event settings following the intentional release of or in response to naturally occurring outbreaks of infectious diseases. This contract may support formulation and manufacture of the individual vaccine components, as well as stability testing, nonclinical immunogenicity and efficacy testing in nonhuman primates, IND enabling GLP repeated dose toxicology, submission of an IND and eventual clinical evaluation.