The Pacific Aging and Cancer Studies (PACS): An Infrastructure Advancing the Use of Digital Biomarkers and Related Technologies for Research on Functional Aging and Survivorship in Cancer

工程 摘要/摘要 通过 为 速度 幸存者。 2040年，65岁以上癌症幸存者的比例将上升到73%，大多数人将存活下来 5年或更长时间1.癌症治疗会加速衰老，并导致新的损伤，而这些损伤可能会 功能丧失的轨迹和加速老年人依赖和残疾的发生 C t 面临功能衰退风险的老年癌症幸存者的数量可能导致显著的 损伤和残疾造成了一个紧迫的公共卫生问题。至 BE 特点 解决这些紧迫问题更必须 已知功能性衰老的轨迹以及它们如何随不同的癌症、治疗方法和宿主而变化 以及它们如何与不同的风险和保护因素相互作用。 癌症和衰老是缺乏现成的方法来捕捉纵向和多维的轨迹 跨越癌症连续体的功能老化。一系列数字技术的最新进展， 包括可穿戴设备、不引人注目的传感器和被动数据收集应用程序将提供更多 对功能性衰老轨迹的呈现和进展的细微和全面的理解 在老年癌症幸存者中。需要专门的研究基础设施来充分发挥数字技术的潜力 老龄化和癌症研究中的技术。NOT-CA-22-030概述NCI参与PA-20-070研究 跨学科老龄化研究的基础设施发展需要R21/R33项目，这些项目提出 发展中 要求 或者扩大一个新的研究基础设施，以促进癌症和衰老的科学 跨学科协作。为了直接响应这些资金需求，我们提出了R21/R33项目 建立基础设施，促进数字生物标记和相关技术的使用，以研究 癌症中的功能老化和生存。我们已经组装了一个高效和协作的 跨学科的研究团队，在癌症生存、老年科学和老龄化、数字化方面拥有专业知识 技术、血液学-肿瘤学和生物统计学。对于此R21/R33阶段性创新奖，我们 跨学科团队提出了以下两个里程碑式的项目：R21项目：适应数字 评估老年癌症幸存者和护理伙伴功能老化的技术平台：目标1) 组建一个社区咨询委员会，听取利益相关者的意见；目标2)进行混合方法研究，以 了解利益相关者对数字技术的利用和看法，以及目标3)创建可供试用的 全远程数字评估协议，旨在最大限度地提高利益相关者的参与度和留存率。R33 项目：建立数字生物标记物在多个功能领域检测有意义变化的能力 在全身癌症治疗期间：目的1)对老年患者进行概念验证纵向研究 和他们的配偶在系统性癌症治疗期间照顾伴侣与功能下降和目标2) 开发和传播一套数字工具和最佳做法，以参与和保留旧的 癌症患者和他们的配偶使用数字技术进行纵向研究。

PROJECT SUMMARY/ABSTRACT By for speed survivors. 2040, the proportion of cancer survivors who are over 65 years of age will rise to 73% and most will survive 5 years or longer 1 . Cancer treatment an accelerate aging and cause new impairments that ogether can the trajectory of functional losses and hasten the onset of dependence and disability among older c t The number of older cancer survivors at risk of functional declines that can lead to significant impairment and disability creates an urgent public health concern. To be characteristics address these urgent problems more must known about trajectories of functional aging and how they vary with different cancers, treatments, and host and how they interact with varying risk and protective factors.A major limitation to research in cancer and aging is the lack of ready methods to capture longitudinal and multi-dimensional trajectories of functional aging across the continuum of cancer. Recent advances across a range of digital technologies, including wearable devices, unobtrusive sensors, and passive data collection applications would provide a more nuanced and comprehensive understanding of the presentation and progression of functional aging trajectories in older cancer survivors. Dedicated research infrastructures are needed to fully realize the potential of digital technologies in aging and cancer research. NOT-CA-22-030 outlines NCI's participation in PA-20-070 Research Infrastructure Development for Interdisciplinary Aging Studies calling for R21/R33 projects that propose developing requiring or scaling up a novel research infrastructure that will advance the science of cancer and aging interdisciplinary collaborations . In direct response to these funding calls, we proposea R21/R33 project to build an infrastructure advancing the use of digital biomarkers and related technologies for research on functional aging and survivorship in cancer. We have assembled a highly productive and collaborative transdisciplinary team of investigators with expertise in cancer survivorship, geroscience and aging, digital technology, hematology-oncology, and biostatistics. For this R21/R33 phased innovation award our transdisciplinary team proposes the following two milestone-based projects: R21 project: Adapt a digital technology platform for assessing functional aging in older cancer survivors and care partners by: Aim 1) assembling a community advisory board for stakeholder input; Aim 2) conducting a mixed-methods study to learn about stakeholder utilization and perceptions on digital technologies and Aim 3) creating a trial-ready and fully remote digital assessment protocol designed to maximize stakeholder engagement and retention. R33 project: Establish the ability of digital biomarkers to detect meaningful change in multiple domains of functioning during systemic cancer treatment by: Aim 1) conducting a proof-of concept longitudinal study in older patients and their spouse care partners during systemic cancer treatment associated with functional decline and Aim 2) developing and disseminating a set of digital tools and best practices for engagement and retention of older patients with cancer and their spouse care partners in longitudinal research using digital technology.