Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)

摘要/摘要（行政核心） 密歇根生命阶段环境暴露和疾病中心（M-LEEaD）的使命有两个 总体目标：加速界定和解释环境暴露影响的研究， 生命的脆弱阶段，并促进这些发现的转化，以改善临床和公共卫生 为减轻人类疾病而采取的干预措施。我们通过综合研究来实现我们的使命， 培训和社区参与由行政核心监督。核心由中心主任领导 Dolinoy在副局长Meeker的协助下。该中心是试点项目的行政单位 计划（由Meeker领导），职业发展计划（由Omenn副总监领导）和翻译 研究计划（由副主任Padmanabhan领导）。研究团队（累积暴露和 人口健康;气候变化与健康差异;毒理学机制与健康结果） 是翻译研究计划的组成部分，团队负责人作为 行政核心。这些团队接受NIEHS转化研究框架中提出的目标， 加强我们中心将基础研究转化为患者和社区的实际应用， 作为成员探索合作和协调供资机会反应的机制。 包括试点项目，职业发展和转化研究计划的领导， 核心解决了中心的目标，这些方案以综合的方式运作。另夕h 社区参与核心（CEC）的领导人是核心的成员，公民联合主席 CEC利益攸关方宣传委员会是核心内部咨询委员会的成员。核心教师是 由一名行政助理、网页设计师和评估员协助。核心负责组织M- LEEaD活动，如会议、务虚会、研讨会和焦点小组，并保存报告记录， 会议记录和这些活动的评价结果。此外，核心委员会还提供信托监督， 预算.核心获得并考虑有关新兴理论、范式和技术的输入， 环境健康科学和生物医学在多个层面，从研究团队报告，以主任 参加内部和外部咨询委员会会议。核心确保各项活动鼓励创新 为所有成员进行研究，特别是早期研究人员，并通过以下方式促进社区参与 M-LEEaD科学家、社区成员和监管利益相关者之间的多方向对话。的 核心协调对紧急环境问题的反应，包括与其他核心中心的互动， NIEHS和相关组织。最后，核心负责评估M-LEEaD的疗效 程序、核心和活动，采取必要的纠正措施。通过这种领导， 行政核心确保高标准的活动，将基础研究成果转化为 实际应用，以推进全面和综合的环境健康模式。

SUMMARY/ABSTRACT (Administrative Core) The Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD) mission has two overarching goals: to accelerate research that defines and explains impacts of environmental exposures during vulnerable stages of life, and to promote translation of these findings to improve clinical and public health interventions for the mitigation of human disease. We implement our mission through integrated research, training, and community engagement overseen by the Administrative Core. The Core is led by Center Director Dolinoy with assistance from Deputy Director Meeker. This Core is the administrative unit for the Pilot Project Program (led by Meeker), Career Development Program (led by Associate Director Omenn), and Translational Research Program (led by Associate Director Padmanabhan). Research Teams (Cumulative Exposures & Population Health; Climate Change & Health Disparities; and Toxicological Mechanisms & Health Outcomes) are elements of the Translational Research Program with team leaders included as members of the Administrative Core. The teams embrace goals set forth in the NIEHS Translational Research Framework to enhance our Center’s translation of basic research into practical applications for patients and communities and serve as a mechanism for members to explore collaborations and coordinate funding opportunity responses. Inclusion of leadership of the Pilot Project, Career Development, and Translational Research programs in the core addresses the Center objective that these programs operate in an integrative manner. Additionally, the leader of the Community Engagement Core (CEC) is a member of the Core, and the citizen co-chair of the CEC Stakeholder Advocacy Board is a member of the Core’s Internal Advisory Committee. Core faculty are assisted by an administrative assistant, web designer, and evaluator. The Core is responsible for organizing M- LEEaD activities such as meetings, retreats, seminars, and focus groups, and maintaining records of reports, minutes, and evaluation results from such events. In addition, the Core provides fiduciary oversight of the budgets. The Core obtains and considers input on emerging theories, paradigms, and technologies in environmental health sciences and biomedicine at multiple levels, from Research Team reports to director meetings to Internal and External Advisory committees. The Core ensures that activities encourage innovative research for all members, but especially for early-stage investigators, and foster community engagement via multi-directional dialogue among M-LEEaD scientists, community members, and regulatory stakeholders. The Core coordinates responses to urgent environmental concerns, including interactions with other core centers, NIEHS, and relevant organizations. Finally, the Core is responsible for evaluation of the efficacy of M-LEEaD programs, cores, and activities, taking corrective action as warranted. Through this leadership, the Administrative Core ensures a high standard of activities for the translation of basic research findings into practical applications to advance a comprehensive and integrated environmental health paradigm.