Training Program on Genetic Variation and Human Phenotypes

项目概要：遗传变异和人类表型的范德比尔特培训计划 支持人类遗传学的博士预科生。我们申请资助8名博士预科生， 资助两年。该计划的使命是准备这些学生成功的 在人类遗传学的学术，工业或公共服务能力的职业生涯。我们准备我们的 学生从以技能为中心的课堂教学开始，过渡到有经验的， 通过研究和与更有经验的导师积极合作进行基础学习。 学生通过他们的研究，定期接触人类遗传学研究的领导者。 合作，研究研讨会，并出席国家和国际会议。这 培训计划取得了广泛的成功，我们的学生实现了卓越的生产力 (mean 5.1，范围2-11，最近资助的学生在研究生院期间的出版物）。学生 对人类遗传学培训的兴奋迅速增加， 进入范德比尔特人类遗传学（HGEN）博士课程的学生人数超过 了过去5年这种日益增长的兴奋在很大程度上来自于前所未有的数据， 现在提供给学生。以前，它可能需要多年的职业发展才能组装 甚至是单一表型的单一大规模队列。然而，随着大型生物银行的出现， 有了临床数据，现在研究生可以相对较快地组装队列， 我们的计划提供的适当培训。范德比尔特HGEN计划一直在 培养研究生在这种新型的研究的前沿。范德比尔特自己的大- 规模生物库（BioVU），现在是NIH“我们所有人”计划的数据和研究中心 位于范德比尔特大学医学中心，我们的研究生已经得到了这两个 在这种新的和开创性的研究类型的实践和正式的教学培训。与 2015年成立范德比尔特遗传学研究所后，范德比尔特致力于 招聘遗传学和基因组学教师的资源，以及对 生物库受试者的基因分型。我们的研究生是全面的生物学家，其中大多数 通过范德比尔特的跨学科研究生课程（IGP）录取，其余的从 定量和化学生物学计划（QCB）。他们以一种惊人的方式进行研究， 各种主题，并在顶级科学期刊上发表研究生论文。他们的教育 明确赋予他们权力，因为学生本身就是自己的主要设计师 范德比尔特内部的合作研究，他们正确地认为，他们不仅受益于 人类遗传学领域的兴奋，但也在推动它。

Project Summary: The Vanderbilt Training Program in Genetic Variation and Human Phenotypes supports predoctoral students in human genetics. We request funding for 8 predoctoral students, funded for two years. The mission of this program is to prepare these students for a successful career in human genetics in an academic, industrial, or public service capacity. We prepare our students beginning with skills-focused classroom instruction and transitioning to experienced- based learning through research and active collaboration with more experienced mentors. Students are regularly exposed to leaders in human genetics research through their collaborations, research seminars, and attendance at national and international meetings. This training program has enjoyed broad success, with our students achieving excellent productivity (mean 5.1, range 2-11, publications during graduate school by recently funded students). Student excitement for human genetics training has rapidly increased, demonstrated by a 3-fold increase in the number of students entering the Vanderbilt Human Genetics (HGEN) PhD program over the past 5 years. Much of that increased excitement has grown from the unprecedented data available now to students. Previously, it could take years of career advancement to assemble even a single large-scale cohort of a single phenotype. However, with the advent of large biobanks with clinical data, cohorts can now be assembled relatively quickly by graduate students with the proper training, which our program provides. The Vanderbilt HGEN program has been at the forefront of training graduate students in this new type of research. With Vanderbilt’s own large- scale biobank (BioVU), and now the Data and Research Center for the NIH “All of Us” program located in the Vanderbilt University Medical Center, our graduate students have been getting both hands-on and formal didactic training in this new and groundbreaking type of research. With the establishment in 2015 of the Vanderbilt Genetics Institute, Vanderbilt has committed substantial resources for recruitment of faculty in genetics and genomics and additional investment in genotyping of biobank subjects. Our graduate students are well-rounded biologists, with most matriculating through the Interdisciplinary Graduate Program (IGP) at Vanderbilt and the rest from the Quantitative & Chemical Biology Program (QCB). They conduct research in an amazing variety of topics and publish as graduate students in the top scientific journals. Their education is clearly empowering them, as the students themselves are major designers of their own collaborative research within Vanderbilt, and they rightly feel that they are not just benefitting from the excitement in the field of human genetics today but are also driving it.