South Texas Alzheimer's Disease Center

阿尔茨海默病S病及相关疾病对拉美裔/拉丁裔的影响不成比例，世卫组织 表现出更高的发病率、更早的发病并面临独特的挑战，原因是文化、语言、社会经济或 医疗服务准入问题。此外，墨西哥缺乏专注于ADRD的研究人员- 美国(MA)拉美裔，是美国增长最快的少数民族。解决ADRD的异构性 演示文稿和生物学，使用精准医学方法改进风险预测，有针对性地预防 而且治疗可能会改善MA和其他人的结果。提议的南得克萨斯州阿尔茨海默病 中心(STAC)将利用其在德克萨斯州南部的独特地理位置，该地区约有500万人口，服务不足 MA将开发基础设施和数据/生物样本收集，以支持来自多个国家的研究人员 学科进行研究，以减轻拉美裔AD的负担。我们有6个具体目标：(1) 从患者、控制者和照顾者那里收集和共享纵向数据(2)探索 临床前和临床痴呆的异质性，通过临床、影像、遗传、 所有这些参与者的基因组、脑脊液、血液和感觉运动生物标记物和尸检(3)特别关注 目标#1和#2针对西班牙裔/拉丁裔个人(4)确定痴呆风险的新预测因素/生物标记 和恢复力，包括对临床病理亚群的了解较少，如疑似非阿尔茨海默病 (淀粉样蛋白阴性，神经变性阳性)患有/不患有糖尿病的西班牙裔人的病理学[SNAP]，(5)至 招募、培训、指导和支持多样化的研究队伍，主要是妇女和少数族裔，以成为 多学科、以团队为基础的ADRD研究、(6)双向社区教育和 参与，研究知识、态度和做法/偏好。STAC将开发和共享 统一数据集以外的文化敏感的深层表型方法(包括新的认知， 行为、血管、生活方式因素、生物标志物)、遗传学和社区内的多维组学- 以病人和照顾者(二元)为基础的队列。使用最新的临床信息学和统计学 方法，这些丰富的数据应该可以探索ADRD的分子异质性并发现 新的生物学和药物靶点，治疗方法。最后，我们将进行协作，共享数据/样本并 与德克萨斯州和世界各地的其他机构，特别是其他ADRC中心、NACC、 NCRAD，NIAGADS。我们将通过建立六个必要的核心和一个组成部分来实现这些目标： 行政、临床、数据管理和统计、神经病理学、外展、招聘和 参与、生物标记核心和研究教育部分。此外，我们还提出了三个 可选核心：人群神经科学、成像和遗传学以及多组学核心。STAC将为 作为颠覆性、变革性和创新性研究和设计、开发、 测试和实施切实可行的战略，以减轻拉美裔美国人的AD负担。

Alzheimer´s disease (AD) and related disorders (ADRD) disproportionally impacts Hispanics/Latinos, who exhibit higher rates, earlier onset and face unique challenges due to cultural, linguistic, socioeconomic or healthcare access problems. Moreover, there is a shortage of researchers focused on ADRD in Mexican- American (MA) Hispanics, the fastest growing minority in the US. Addressing the heterogeneity of ADRD presentation and biology, using precision medicine approaches to improve risk prediction, target prevention and treatment is likely to improve outcomes for MA and others. The proposed South Texas Alzheimer disease Center (STAC) will exploit its unique geographic location in South Texas, a region of ~5 million, underserved MA to develop infrastructure and data/biosample collections that will support researchers from multiple disciplines to conduct research to diminish the burden of AD in Hispanics. We have 6 specific aims: (1) Collecting and sharing longitudinal data from patients, controls and caregivers (2) Exploring the biological heterogeneity of preclinical and clinical dementia, through deep phenotyping with clinical, imaging, genetic, omic, CSF, blood and sensory-motor biomarkers and autopsy of all these enrollees (3) Focusing especially for Aims #1 and #2 on Hispanic/Latino individuals (4) Identifying novel predictors/ biomarkers of dementia risk and resilience, including for poorly understood clinic-pathologic subgroups such as Suspected Non-Alzheimer (amyloid negative, neurodegeneration positive) Pathology [SNAP] in Hispanics with/without diabetes, (5) To recruit, train, mentor and support a diverse research workforce, largely women and minorities, to become leaders in multidisciplinary, team-based, ADRD research, (6) Bidirectional community education and engagement, research into knowledge, attitudes and practices/preferences. The STAC will develop and share culturally sensitive deep phenotyping methods beyond the Uniform Dataset (including novel cognitive, behavioral, vascular, lifestyle factors, biomarkers), genetics and multi- dimensional omics within community- based and patient and caregiver (dyadic) cohorts. Using state of the art clinical informatics and statistical methods, these rich data should permit an exploration of the molecular heterogeneity of ADRD and uncover novel biology and drug targets, treatment approaches. Finally we will collaborate, share data/samples and expertise with other institutions in Texas and around the world, especially other ADRC Centers, the NACC, NCRAD, NIAGADS. We will achieve these aims through creation of six required Cores and one component: Administrative, Clinical, Data Management and Statistical, Neuropathology, Outreach, Recruitment and Engagement, Biomarker Cores and the Research Education Component. In addition, we propose three Optional Cores: Population Neuroscience, Imaging and Genetics and Multiomics Cores. The STAC will serve as a national resource for disruptive, transformative and innovative research and the design, development, testing and implementation of practical strategies to diminish the burden of AD in Hispanics.