National Longitudinal Study of Adolescent to Adult Health (Add Health): Wave VI Cognition and Early Risk Factors for Dementia Project

项目摘要 预计到2050年，阿尔茨海默氏症和相关痴呆症(ADRD)将影响1400万美国人。至 然而，迄今为止，关于ADRD症状和体征的研究在中年早期人群中还很稀少， 特别是在国家层面。进行这样的研究是至关重要的，因为认知的早期变化 ADRD的功能和风险因素的积累可能在出现具体迹象和 症状就会出现。对ADRD病因的富有挑战性的探索清楚地表明， 全面的数据--包括生命过程中详细的社会、生物和健康测量- 需要确定ADRD的关键预测因素。因此，全国青少年到成年人的纵向研究 健康(Add Health)为研究认知的早期起源提供了一个非同寻常的机会 国家代表性队列中的功能/变化和ADRD风险 在下一波数据收集(第六波)中，他们处于青春期，将在40岁左右。这个项目的总体目标是 该项目是收集和传播与认知、身体和感觉功能有关的关键数据 与Add Health Wave VI核心项目相结合，促进识别晚年生活的早期风险因素 阿德勒。将这种丰富的措施添加到Add Health的第六波将使跟踪认知、感觉和 和生命过程中的身体功能；再加上生物风险标记物的测试，它还将 在中年早期检测认知障碍迹象和ADRD风险的基础。这些新数据， 与Add Health现有的25年来异常丰富的多层次和纵向 措施及其新的第六波数据也将有助于科学界了解 在晚年导致ADRD的社会、行为和生物因素。此外，因为增加健康是一个非常重要的因素 多样化的样本，将这些数据添加到第六波将极大地提高对认知、身体和 健康差距人群中的感觉功能。该项目的具体目标是：1)收集新的- 深入、亲自评估中年早期的认知功能，为具有全国代表性的 第六波参与者的种族/民族多样性；2)收集自动化的(主要)基于网络的 VI波中所有参与者在中年早期的认知测量，并与我们的面对面比较 评估其可行性和价值的认知措施；3)包括身体和感官评估 Add Health第六波参与者中年早期的功能；4)ADRD风险的生物标志物测试 和中年早期的认知功能；5)清理、记录、传播、推广和支持数据 在这个项目中为科学界收集的。总而言之，这个项目将收集和传播创新 向数千名研究人员提供数据，这将有助于对未来生活中的认知和风险因素进行严格研究 ADRD在早期中年美国人中具有全国代表性的多样化样本中。

Project Summary Alzheimer's Disease and Related Dementias (ADRD) are projected to affect 14 million Americans by 2050. To date, though, research on the signs and symptoms of ADRD has been sparse in early midlife populations, especially at the national level. It is crucial to conduct such research because early changes in cognitive functioning and the accumulation of risk factors for ADRD can begin decades before concrete signs and symptoms emerge. The challenging search for the causes of ADRD has made it clear that prospective and comprehensive data—including detailed social, biological, and health measurements across the life course— are needed to identify key predictors of ADRD. As such, the National Longitudinal Study of Adolescent to Adult Health (Add Health) provides an extraordinary opportunity to study the early origins of cognitive functioning/change and ADRD risk in a nationally representative cohort that has been followed since adolescence and will be in their mid-40s in the next wave of data collection (Wave VI). The overall goal of this project is to collect and disseminate critical data related to cognitive, physical, and sensory functioning in conjunction with the Add Health Wave VI Core Project to facilitate identification of early risk factors for later life ADRD. Adding such rich measures to Wave VI of Add Health will make possible tracking of cognitive, sensory, and physical functioning across the life course; coupled with the testing of biological risk markers, it will also lay the foundation for detecting signs of cognitive impairment and ADRD risk in early midlife. These new data, when combined with Add Health's existing 25-year collection of extraordinarily rich multi-level and longitudinal measures and its new Wave VI data, will also aid in the scientific community's understanding of the interplay of social, behavioral, and biological factors leading to ADRD in later life. Moreover, because Add Health is a very diverse sample, adding these data to Wave VI will greatly increase understanding of cognitive, physical, and sensory functioning within health disparity populations. The project's specific aims are to: 1) Collect new in- depth, in-person assessments of cognitive functioning in early midlife for a nationally representative and racially/ethnically diverse subsample of participants in Wave VI; 2) Collect automated, (largely) web-based measures of cognition in early midlife for all participants in Wave VI and compare them with our in-person measures of cognition to assess their feasibility and value; 3) Include assessments of physical and sensory functioning in early midlife for Wave VI participants of Add Health; 4) Test for biological markers of ADRD risk and cognitive function in early midlife; 5) Clean, document, disseminate, promote, and support the data collected in this project for the scientific community. All told, this project will collect and disseminate innovative data to thousands of researchers that will facilitate the rigorous study of cognition and risk factors for later life ADRD among a diverse nationally representative sample of early midlife Americans.