Comprehensive Research Experiences to Advance Training and Education (CREATE) for Future Cancer Researchers

项目摘要 尽管在诊断和治疗方面取得了重大进展，但仍然需要持续的研究和 治疗创新，以减少癌症负担。除了实验生物学，肿瘤学的前景 研究现在包括计算患者数据集挖掘新的生物标志物和治疗靶点， 基于基因组和表观基因组分析的个性化医疗，以及社会人口和 社会经济差异影响癌症发病率和结果。下一代研究人员必须 接受早期接触这种全面的，现代肿瘤学的综合观点，使他们能够了解 和创新的决定，在整个未来的专业化或交叉专业化的选择 教育为未来癌症研究人员提出的CREATE计划旨在实现这一目标， 将为期10周的指导性本科癌症研究计划与基础模块相结合， 计算药物发现和开发以及基于癌症健康风险的研究。此程序将 建立和扩大UMMSOM/西尔维斯特综合癌症中心（SCCC）赞助的现有 暑期课程基础设施，以促进研究项目量身定制，以个人学者的兴趣， 全面的学术和职业发展支持。作为补充，通过一个动手的小项目， CREATE学者将接受生物信息学和计算方法方面的实践指导， 建立一个强大的治疗管道。SCCC服务于多样化的集水区， 创造学者与独特的机会，了解癌症差异在社区的影响 疾病发生率和治疗结果的水平。目前，只有本科生积极参与 计算项目或健康差异研究从这些基本研究中受益 地区我们建议的课程将确保我们所有的学者发展这些领域的工作理解， 除了完成实质性的板凳研究与世界一流的教师导师。创造学者将 我也经历了临床肿瘤学的组成部分，包括医生的影子和第一阶段的基本指导 试验设计他们将获得持续的方案和同行指导支持，因为他们导航下一个 在他们的学术训练的步骤。加强癌症研究队伍的一个重要方面是推广 与学生群体谁没有研究的机会，由于他们的位置，或 情节SCCC是整个佛罗里达州第二个NCI指定的中心。所以我们的 机构夏季计划收到更多的合格申请人比我们可以支持，表明一个明确的 全国大学生对我们的癌症研究资源和环境的兴趣。是的， 因此，在提供创新的CREATE计划以帮助产生下一代癌症方面， 研究人员与全面的培训和知识，在肿瘤学为基础的事业取得成功。

Project Summary Despite major advances in diagnosis and treatment, there remains a need for sustained research and therapeutic innovation to reduce cancer burden. Besides experimental biology, the landscape of oncology research now encompasses computational patient dataset mining for new biomarkers and therapeutic targets, genome and epigenome analysis-based personalized medicine, and application of how sociodemographic and socioeconomic disparities affect cancer incidence and outcomes. The next generation of researchers must receive early exposure to this comprehensive, integrated view of modern oncology, so they can make informed and innovative decisions regarding specialization or cross-specialization options throughout their future education. The proposed CREATE program for future cancer researchers aims to accomplish this goal by integrating a 10-week mentored undergraduate cancer research program with foundational modules on computational drug discovery and development and cancer health disparities-based research. This program will build and expand on the UMMSOM/Sylvester Comprehensive Cancer Center (SCCC)-sponsored pre-existing summer program infrastructure to facilitate research projects tailored to individual scholar interest alongside comprehensive academic and career development support. Complementarily, through a hands-on mini-project, CREATE scholars will receive hands-on instruction in bioinformatics and computational approaches required to develop a robust therapeutic pipeline. SCCC serves a diverse catchment area that will be leveraged to provide CREATE scholars with unique opportunities for understanding the impact of cancer disparities at the community level on disease incidence and treatment outcomes. Currently, only undergraduates actively engaged in computational projects or health disparities research benefit from their exposure to these essential research areas. Our proposed curriculum will ensure all our scholars develop a working understanding of these areas in addition to accomplishing substantive bench research with world-class faculty mentors. CREATE scholars will also experience clinical oncology components including physician shadowing and basic instruction in Phase I trial design. They will receive sustained programmatic and peer mentoring support as they navigate the next steps in their academic training. An important aspect of enhancing the cancer research workforce is outreach and engagement with student populations who do not have research opportunities due to their location or circumstances. SCCC is only the second NCI-designated center in the entire state of Florida. As such, our institutional summer program receives more qualified applicants than we can support, demonstrating a clear interest from undergraduates across the country in our cancer research resources and environment. We are, thus, in a unique position to offer the innovative CREATE program to help produce the next generation of cancer researchers with the comprehensive training and knowledge to succeed in oncology-based careers.