Understand biological factors underlying early childhood caries disparity from the oral microbiome in early infancy

项目摘要 幼儿龋齿（ECC）对低收入家庭的儿童影响不成比例， 少数民族社区。口腔微生物群失调，包括致龋细菌的富集和 酵母，增加ECC的风险。以前的研究表明，子宫内和早期生活之间的联系 营养摄入和肠道微生物组发育。然而，宫内和生命早期营养摄入对 母亲和儿童的口腔微生物组仍不清楚。作为家长奖的一个补充 R01DE031025早期婴儿口腔微生物组（OMEI），我们提出了这种补充OMEI +营养。的 父母OMEI研究早期生命的生物学因素的基础ECC种族差异通过一个宝贵的服务不足， 出生队列在OMEI+营养补充中，我们将因素扩展到包括围产期营养（如 膳食铁摄入量）和非营养性行为（如异食癖），以检查其与口服 微生物组在怀孕和生命早期。 我们的中心假设是，有非营养性饮食行为的母亲与一种独特的 口腔微生物群落，影响儿童早期口腔微生物组的发育。我们建议 OMEI + Nutrition研究的目标。目的1：评估营养性和非营养性饮食的影响 行为对孕妇口腔微生物组的影响。目标2：评估孕产妇营养和保健对妇女的影响， 非营养性饮食行为对婴儿早期（出生至6个月）口腔念珠菌定植和酵母菌的影响 感染目的3（探索性）：评估异食癖物质的微生物组成。 OMEI + Nutrition将是第一个研究营养与健康之间关系的研究。 (such如膳食铁摄入量）和非营养因素（如异食癖）对围产期口腔微生物组的影响 美国孕妇和她们的孩子。生成的数据将加强 了解儿童口腔微生物组的发育及其与ECC的关系。其他风险因素 从这个OMEI+营养揭示将被用作产前咨询，ECC早期预测和 预防，特别适合服务不足的妇女和儿童。 这OMEI +营养将进行的多样性补充申请人，博士布伦达阿布， 营养学家兼研究员，她将在已经整合的基础上添加她丰富的营养和饮食学背景 健康差异研究小组。阿布博士热情地打算发展她的职业生涯中的互动， 营养和口腔健康。这OMEI +营养补充剂将推进 她在口腔健康和口腔微生物组研究方面的技能和专业知识，将为 未来的R01应用程序，评估母亲和儿童口腔和口腔微生物的饮食行为和口腔微生物组， 系统健康。

Project Summary Early childhood caries (ECC) disproportionately affects children from low-income households and ethnic minority communities. Dysbiosis of oral microbiota, including enrichment of cariogenic bacteria and yeast, increase the risk for ECC. Previous research indicated connections between in-utero and early-life nutrition intake and gut microbiome development. Yet, the impact of in-utero and early-life nutrition intake on maternal and children’s oral microbiome remains unclear. As an augmentation to the parent award R01DE031025 Oral Microbiome in Early Infancy (OMEI), we propose this supplement OMEI + Nutrition. The parent OMEI studies the early-life biological factors underlying ECC racial disparity via a valuable underserved birth cohort. In the OMEI+ Nutrition supplement, we expand the factors to include perinatal nutritive (such as dietary iron intake) and nonnutritive behavior (such as pica) to examine their potential relationships with oral microbiomes during pregnancy and early life. Our central hypothesis is that mothers with nonnutritive eating behavior are associated with a distinct oral microbial community, which influences oral microbiome development in early childhood. We propose the following aims in the OMEI + Nutrition study. Aim 1: Assess the effect of nutritive and nonnutritive eating behavior on the oral microbiome of pregnant women. Aim 2: Assess the impact of maternal nutritive and nonnutritive eating behavior on infants' early-life (birth to 6 months) oral Candida colonization and yeast infection. Aim 3 (Exploratory): assess microbial compositions of pica substances. The OMEI + Nutrition will be the first study that examines the relationship between nutritive (such as dietary iron intake) and nonnutritive (such as pica) factors on perinatal oral microbiome among underserved US pregnant women and their children. Data generated will strengthen the understanding of children’s oral microbiome development and their association to ECC. Additional risk factors revealed from this OMEI+ Nutrition would be used as targets for prenatal counselling, ECC early prediction and prevention, specifically suitable for underserved women and children. This OMEI + Nutrition will be conducted by the diversity supplement applicant, Dr. Brenda Abu, a Nutritionist-Researcher, who will add her strong nutrition and dietetics background to the already integrated health disparities research team. Dr. Abu enthusiastically intends to develop her career in the interaction of nutrition and oral health among the underserved population. This OMEI + Nutrition supplement will advance her skills and expertise in oral health and oral microbiome research, which will build a solid foundation for a future R01 application that assesses eating behavior and oral microbiome on maternal and children’s oral and systemic health.