Stanford Diabetes Research Center

中心概述：项目总结/摘要 斯坦福大学糖尿病研究中心（SDRC）体现了斯坦福大学的战略计划的高潮 大学医学院创建一个一流的计划，建立在一流的基础上， 糖尿病研究中基础、临床和转化问题的研究者。SDRC的使命是 促进糖尿病相关研究的创新、新知识和培训，从而改善诊断， 治疗，并最终预防和治愈糖尿病及其并发症。更新此P30 应用程序将利用斯坦福大学的糖尿病研究，提供关键资源，致力于 支持以糖尿病为重点的调查和丰富活动。斯坦福大学有着悠久的传统， 学术卓越，创新和临床护理，团结在一个真正的大学在一个单一的校园，培养 来自不同学科的科学家和临床医生之间的互动。斯坦福大学位于硅谷的中心 硅谷是创新和计算风险的中心，其公司与SDRC教师合作， 独特和不断增长的合作，以推进糖尿病研究和护理。斯坦福大学与两所大学相邻 加州大学伯克利分校和戴维斯分校，这两个精英研究中心的糖尿病研究基地不断扩大 未连接到NIDDK DRC。SDRC由来自斯坦福大学3所学校的124名成员组成， 加州大学伯克利分校和加州大学戴维斯分校的多所学校。斯坦福大学的SDRC成员目前拥有65，044，250美元， 糖尿病相关研究的年度直接费用。SDRC成员由专注于 (i)胰岛和胰腺生物学，（ii）代谢和信号传导，（iii）免疫学，移植和干细胞生物学， 及（iv）生物工程及行为科学。SDRC包括：（1）行政部门， 协调科学、组织、充实、培训和外联活动，（2）生物医学研究 招募和选择成员的组成部分，并监督4个研究核心，促进和加强 他们的研究，和（3）一个成功的SDRC试点和可行性（P&F）奖励计划，促进 糖尿病研究的早期阶段的研究人员，并建立新的科学家糖尿病研究。我们 我建议扩大这一计划，包括一个区域P&F计划，支持在加州大学戴维斯分校的研究， 伯克利NIH对SDRC的支持被以下因素放大：（1）斯坦福大学持续承诺提供空间， 重要的财政资源，（2）一系列全面的机构研究核心，使NIDDK 基金，以支持专门的SDRC研究核心致力于糖尿病研究，（3）合作努力， 其他斯坦福大学研究中心，以及（4）SDRC成员领导的高知名度的国家糖尿病研究 努力自2017年P30资助开始以来，SDRC已经发展，包括其调查员基础的增长， 加强对转化研究的关注，并为核心服务的修改提供不可或缺的支持 用于糖尿病研究。从多个指标来看，SDRC是创新的力量倍增器，其成员使 与基础和转化糖尿病、肥胖和代谢研究相关的开创性科学贡献。

CENTER OVERVIEW: PROJECT SUMMARY/ABSTRACT The Stanford Diabetes Research Center (SDRC) embodies the culmination of a strategic plan by the Stanford University School of Medicine to create a premier program founded on a base of superb, collaborative investigators studying basic, clinical and translational problems in diabetes research. The SDRC mission is to foster innovation, new knowledge, and training in diabetes-related research, leading to improved diagnosis, treatment, and ultimately, prevention and cure of diabetes and its complications. Renewal of this P30 application will leverage diabetes research at Stanford University by providing crucial resources dedicated to supporting investigations and enrichment activities focused on diabetes. Stanford has a strong tradition of academic excellence, innovation, and clinical care, united in a true University on a single campus that fosters interactions between scientists and clinicians from different disciplines. Stanford is in the heart of Silicon Valley, an epicenter of innovation and calculated risk-taking, whose companies partner with SDRC faculty in unique and growing collaborations to advance diabetes research and care. Stanford neighbors two Universities of California (UC) at Berkeley, and at Davis, both elite research centers with a growing diabetes research base unconnected to a NIDDK DRC. The SDRC is comprised of 124 members from 3 Schools at Stanford, and from multiple Schools at UC Berkeley and UC Davis. SDRC members at Stanford currently have $65,044,250 in annual direct costs for diabetes-related research. SDRC members are organized by affinity groups focused on (i) Islet & Pancreas Biology, (ii) Metabolism & Signaling, (iii) Immunology, Transplantation & Stem Cell Biology, and (iv) Bioengineering & Behavioral Sciences. The SDRC consists of: (1) Administrative Component that coordinates scientific, organizational, enrichment, training and outreach activities, (2) Biomedical Research Component that recruits and selects members, and supervises 4 Research Cores that facilitate and enhance their research, and (3) a successful SDRC Pilot and Feasibility (P&F) Award Program that promotes the diabetes research of early stage investigators, and established scientists new to diabetes research. We propose to expand this Program to include a Regional P&F Program that supports research at UC Davis and Berkeley. NIH support for the SDRC is amplified by (1) Stanford’s sustained commitment to provide space and significant financial resources, (2) a comprehensive array of institutional research cores, which allow NIDDK funds to support specialized SDRC research cores devoted to diabetes research, (3) collaborative efforts with other Stanford research centers, and (4) SDRC member leadership of high-profile national diabetes research efforts. Since P30 funding began in 2017, the SDRC has evolved, including growth of its investigator base, intensified focus on translational research, and modification of core services to provide indispensable support for diabetes research. By multiple metrics, the SDRC is a force multiplier of innovation, whose members make seminal scientific contributions related to basic and translational diabetes, obesity, and metabolism research.