The Development of Eating Behavior in Infancy: Associations with Behavior, Diet, and Growth to Age 6 years

项目摘要 饮食行为与饮食质量和体重增加密切相关。鉴于饮食的相关性 行为对儿童和成人健康的影响，关于这些行为的发展， 从婴儿期开始的行为，以及它们在儿童期的连续性（或不连续性）。饮食行为可以 通过严格测量暴露于不同刺激后的行为，在婴儿期进行表型分析， 仔细的实验对照，尽管在R01HD084163之前没有研究对多次进食进行表型分析 在一个单一的纵向婴儿队列的客观行为。饮食行为在婴儿期之间可能是可以改变的 和幼儿期，可能会改变与未来饮食质量或体重增加的任何关联。干预措施 促进适应性的母亲喂养做法在降低肥胖风险方面是有效的。干预 根据儿童的特点进行调整，效果可能会进一步加强。识别 在一项观察性研究中，仔细分型的儿童饮食行为和母亲喂养习惯的相互作用 队列研究是今后制定有针对性的干预措施的重要第一步。拟议工作 将第一次检查广泛表型饮食行为的连续性（或不连续性）， 婴儿期，根据新的客观措施和母亲报告，至5岁。这项工作将首先 时间，测试是否母亲喂养的做法和婴儿的饮食行为相互作用，以预测儿童的饮食 5岁时的行为，以及6岁时的饮食质量和BMI。ABC婴儿研究 （R01HD 084163，2015年7月1日至2020年6月30日）及其辅助资助的研究使用新型行为方案， 2周龄、2、4、6、9和6周龄纵向表型饮食行为和母体喂养习惯 12个月的286名婴儿的队列。目前的申请建议对其中200名儿童进行跟踪， 目的1：测试儿童之间的交叉滞后关联， 婴儿期和5岁时的饮食行为和母亲喂养习惯。我们假设这个孩子 婴儿期的饮食行为可预测5岁时的儿童饮食行为， 预测母亲5岁时的喂养习惯，婴儿期的儿童饮食行为预测母亲喂养 母亲在婴儿期的喂养习惯可以预测儿童5岁时的饮食行为。目标二： 为了验证婴儿期测量的饮食行为对婴儿的饮食行为有直接和间接影响的假设， 5岁时的行为）与6岁时的饮食质量和BMI相关。目标3：测试 婴儿期母亲的喂养方式会调节婴儿饮食行为与 5岁时的饮食行为，以及5岁时的母亲喂养习惯会减轻饮食的关联 婴儿期的行为与6岁时的饮食质量和BMI，以及饮食与肥胖的中度相关性。 5岁时的行为与6岁时的饮食质量和BMI。

PROJECT SUMMARY Eating behaviors are robustly associated with dietary quality and weight gain. Given the relevance of eating behaviors to health in children and adults, remarkably little is known regarding the development of these behaviors from infancy, and their continuity (or discontinuity) into childhood. Eating behaviors can be phenotyped in infancy through rigorous measurement of behavior following exposure to different stimuli under careful experimental control, though no studies prior to R01HD084163 have phenotyped multiple eating behaviors objectively in a single longitudinal infant cohort. Eating behavior may be modifiable between infancy and early childhood, potentially altering any associations with future dietary quality or weight gain. Interventions that promote adaptive maternal feeding practices have been effective in reducing obesity risk. Intervention effects might be further strengthened by tailoring to characteristics of the individual child. Identifying interactions of carefully phenotyped child eating behavior and maternal feeding practices in an observational cohort study is an important initial step towards future tailored intervention development. The proposed work will examine for the first time the continuity (or discontinuity) of extensively phenotyped eating behaviors in infancy, based on novel objective measures and maternal report, to age 5 years. The work will, for the first time, test whether maternal feeding practices and infant eating behaviors interact to predict child eating behaviors at age 5 years, as well as dietary quality and BMI at age 6 years. The ABC Baby study (R01HD084163, 7/1/15-06/30/20) and its ancillary funded studies used novel behavioral protocols to phenotype eating behavior and maternal feeding practices longitudinally at ages 2 weeks, and 2, 4, 6, 9, and 12 months in a cohort of 286 infants. The current application proposes to follow up with 200 of these children at ages 5 and 6 years to address the following aims: Aim 1: To test the cross-lagged associations between child eating behaviors and maternal feeding practices across infancy and age 5 years. We hypothesize that child eating behaviors in infancy predict child eating behaviors at age 5 years, maternal feeding practices in infancy predict maternal feeding practices at age 5 years, child eating behaviors in infancy predict maternal feeding practices at 5 years, and maternal feeding practices in infancy predict child eating behaviors at 5 years. Aim 2: To test the hypothesis that eating behaviors measured in infancy have direct and indirect (through eating behaviors at age 5 years) associations with dietary quality and BMI at age 6 years. Aim 3: To test the hypotheses that maternal feeding practices in infancy moderate associations of infant eating behaviors with eating behaviors at 5 years, and that maternal feeding practices at 5 years moderate associations of eating behaviors in infancy with dietary quality and BMI at age 6 years, and moderate associations of eating behaviors at age 5 years with dietary quality and BMI at age 6 years.