Irradiation and Animal Core

项目总结/摘要 癌症治疗副作用生物学的转化研究在很大程度上依赖于复杂的体内 研究模型，需要特定的专业知识来设计，开发，实施， 故障排除新的研究人员经常遇到启动问题时，他们的研究需要使用 这些模型。辐照和动物核心（核心C）的主要目的是促进 中心研究人员开发和使用临床前动物模型和放射生物学原理 研究宿主对癌症治疗的反应和校园内的其他COBRE中心。次级 其目标是将核心研究中心发展成为一个自我维持的设施，为整个研究基础设施做出贡献 机构的。在项目的第一阶段，核心为辐射研究建立了强大的基础设施， 小动物的分辨率超声成像，以及动物饲养和处理程序。辐射和 我们还向我们机构的所有研究人员提供超声服务，并收取服务费， 该地区的其他人。在第二阶段，核心将在此基础上提供项目领导和试点 拥有开发和维护动物和辐射模型资源的项目受赠方（目标1）， 为畜牧业和辐射生物学的早期研究人员提供指导和培训（Aim 2），并将核心发展成为一个自我维持的设施，以改善校园内的研究基础设施 (Aim 3）。该中心将在转基因动物模型的建立、 机构动物护理和使用委员会，实施最佳动物育种计划， 其他畜牧业问题，以及高分辨率超声成像的使用。此外，核心 维持5个最先进的X射线和γ射线实验设施。核心人员确认， 进行维护、校准和辐射剂量测定以保证高质量的辐射服务， 他们在放射生物学问题上提供专家建议，协助中心研究人员制定适当的 辐射模型的研究，并协助他们在使用辐照器。核心服务广告，费用 将继续维持时间表和编制预算报告，并在必要时加以优化。定期 对核心用户的调查将确定可能需要的其他服务，并与COBRE和机构 支持，这些服务将得到发展。Core C提供的服务将通过以下方式影响中心的研究： 协助中心研究人员设计和开发他们的研究模型，并提供学习 经验，这将提高他们的专业发展成为独立的研究人员在癌症领域 治疗的副作用此外，核心将丰富现有调查人员的研究基础设施。

PROJECT SUMMARY/ABSTRACT Translational research into the biology of cancer therapy side effects relies heavily on complex in vivo research models that require specific expertise for their design, development, implementation, and troubleshooting. New investigators frequently experience startup problems when their research requires the use of these models. The primary objective of the Irradiation and Animal Core (Core C) is to facilitate the development and use of pre-clinical animal models and radiobiological principles by investigators in the Center for Studies of Host Response to Cancer Therapy and other COBRE Centers on campus. The secondary objective is to develop the core into a self-sustaining facility that contributes to the overall research infrastructure of the institution. During Phase 1 of the project, the core built a strong infrastructure for radiation research, high- resolution ultrasound imaging of small animals, and animal breeding and handling procedures. Radiation and ultrasound services also were made available as a fee-for-service to all investigators from our institution and others in the region. During Phase 2, the core will build on this foundation to provide project leaders and pilot project grantees with resources for the development and maintenance of animal and radiation models (Aim 1), to provide mentoring and training for early-stage investigators in animal husbandry and radiation biology (Aim 2), and to develop the core into a self-sustaining facility that improves the research infrastructure on campus (Aim 3). The core will advise on and assist with the generation of transgenic animal models, the navigation of the Institutional Animal Care and Use Committee, the implementation of optimal animal breeding schemes and other animal husbandry issues, and the use of high-resolution ultrasound imaging. Additionally, the core maintains 5 state-of-the-art experimental X-ray and γ-ray facilities. Core personnel confirm that the necessary maintenance, calibration, and radiation dosimetry are performed to guarantee high-quality radiation services, and they provide expert advice in radiobiological matters, assist Center investigators in developing appropriate radiation models for their research, and assist them in the use of the irradiators. Core services advertising, fee schedule maintenance, and budget report preparation will continue and will be optimized if necessary. Regular surveys among core users will identify additional services that may be required, and with COBRE and institutional support, such services will be developed. The services provided by Core C will impact the Center's research by assisting Center investigators in the design and development of their research models and offer learning experiences that will enhance their professional development into independent researchers in the area of cancer therapy side effects. Moreover, the core will enrich the research infrastructure for established investigators.