Acute Lymphoblastic Leukemia and the Bone Marrow Microenvironment

本研究旨在寻找治疗儿童和成人急性淋巴细胞白血病（ALL）的新药。我们已经确定了干扰骨髓和白血病细胞之间相互作用的药物，并假设这些药物将增加目前使用的化疗的效力。我们将在人类白血病的动物模型中测试这些药物。通过分析这些新药的效果，我们也将了解如何进一步改进治疗方法。

This research aims to identify new drugs for the treatment of childhood and adult acute lymphoblastic leukemia (ALL). We have identified drugs that interfere with interactions between the bone marrow and leukemic cells and hypothesise that these will increase the potency of currently used chemotherapy. We will test these agents in animal models of human leukemia. By analysing the effects of these new drugs we will also understand how we can further improve treatments.