Adult Changes in Thought (ACT) Research Program

成人思维变化(ACT)U19计划将扩大、现代化和改善ACT的前景 在对一般老年人和痴呆症的科学理解方面取得进展的队列研究 尤其是阿尔茨海默氏症。ACT设置在医疗保健提供系统中。研究小组确定了事件 痴呆症和阿尔茨海默病的病例，并跟踪同意的参与者进行尸检。该计划将 将当前的ACT U01转换为U19，它设想了复杂的多组件计划，将具有 在赛场上有强大的影响力。该计划的首要目标是确定生命过程中的风险因素 为保护认知和预防阿尔茨海默病提供了潜在的干预目标 相关痴呆(ADRD)。总体具体目标是：目标1.扩大ACT队列招生和 实现现代化并改进后续行动，重点是增加种族/族裔多样性和深度表型 生命过程风险因素，认知和身体功能，以及结果，包括神经成像和 以神经病理学为基础的ADRD结果。这些核心将把队列登记人数从2000人扩大到3000人。这个 研究将投资于六个核心：A，行政；B，临床；C，生命历程；D，神经病理学；E， 神经影像；F，数据与分析。这些核心将共同努力，进一步提升ACT的价值 资源，使ACT研究继续成为一系列非凡的科学的基础。至 到目前为止，ACT已达到94.5%的随访指标完成率，并已观察到56,140人年 后续行动。ACT已经确认了1300例痴呆症病例和1000例阿尔茨海默氏症病例。这个 这项研究已经完成了850例身体解剖，并将在这个周期内超过1100例。此外，1,077项ACT 参与者接受了一次核磁共振扫描，其中540人接受了≥2，另外数百人的资金已经到位。目标2.支持 研究老年人ADRD健康功能谱的关键项目。三个项目中心 老年期间大约24小时循环的体力活动、久坐行为和睡眠模式(项目1)， 认知定义的阿尔茨海默病亚组的含义(项目2)，以及潜在的机制 强效抗胆碱能药物和抗高血压药物的神经保护和毒性(项目3)。目标3. 在NIA的指导下，扩大和改进ACT向研究界传播特殊资源的工作 采用公平(可发现、可访问、可互操作和可复制)原则。ACT已被证明是一种 向研究界提供特殊资源，向当地研究同行提供数据和标本， 在全国和世界各地，并为初级调查人员提供指导。我们将继续 在此U19计划中增强我们的数据共享能力。

The Adult Changes in Thought (ACT) U19 Program will expand, modernize, and improve ACT's prospective cohort study to achieve advances in scientific understanding of older adults in general and dementia and Alzheimer's disease in particular. ACT is set in a healthcare delivery system. The study team identifies incident cases of dementia and Alzheimer's disease and follows consenting participants to autopsy. The Program will transform the current ACT U01 to a U19, which envisions complex multi-component programs that will have a powerful influence on the field. The Program's overarching goal is to identify risk factors across the life course that provide potential intervention targets for preserving cognition and preventing Alzheimer's disease and related dementias (ADRD). The Overall Specific Aims are: Aim 1. Expand ACT cohort enrollment and modernize and improve follow-up with emphasis on increasing racial/ethnic diversity and deep phenotyping of life course risk factors, cognitive and physical functioning, and outcomes including neuroimaging and neuropathology based ADRD outcomes. The Cores will expand cohort enrollment from 2,000 to 3,000. The study will invest in six Cores: A, Administrative; B, Clinical; C, Life Course; D, Neuropathology; E, Neuroimaging; F, Data and Analysis. These Cores will work together to further enhance the value of ACT's resources, enabling the ACT study to continue to be the foundation for an extraordinary array of science. To date, ACT has achieved a completeness of follow-up index of 94.5% and has observed 56,140 person-years of follow-up. ACT has identified >1,300 incident dementia cases and >1,000 incident Alzheimer's cases. The study has completed >850 autopsies and will surpass 1,100 autopsies this cycle. Additionally, 1,077 ACT participants had one MRI scan, and 540 have had ≥2, with funding in place for hundreds more. Aim 2. Support key Projects studying the spectrum of healthy functioning to ADRD in older adults. The three Projects center around 24-hour cycle physical activity, sedentary behavior, and sleep patterns in old age (Project 1), the implications of cognitively defined Alzheimer's disease subgroups (Project 2), and mechanisms underlying neural protection and toxicity of strong anticholinergic drugs and antihypertensive drugs (Project 3). Aim 3. Expand and improve ACT's dissemination of exceptional resources to the research community guided by NIA's adopted FAIR (Findable, Accessible, Interoperable, and Reproducible) principles. ACT has proven to be an exceptional resource to the research community, providing data and specimens to research colleagues locally, across the country, and around the world, and provides mentorship to junior investigators. We will continue to enhance our data sharing capabilities in this U19 Program.