Sibling Assessment in Prevention of Pediatric NAFLD in Hispanic Children

摘要 非酒精性脂肪性肝病(NAFLD)是一种与肥胖相关的肝病，影响 据估计，美国有700万儿童。这是肝病最常见的原因。 成人器官移植会增加患糖尿病和心血管疾病的长期风险。 非酒精性脂肪肝对西班牙裔儿童的影响不成比例，是一种特别重要的健康问题 贫富差距。最初的R01研究重点是使用低糖饮食干预来预防 青春期前儿童的非酒精性脂肪肝。拟议的行政补充研究是为 将项目扩大到主要参与者的兄弟姐妹，并增加对以下方面的反应评估 对糖尿病危险因素进行干预。这一发现将具有持续性和重大意义 对西班牙裔儿童健康促进的影响，减少健康差距，并提供信息 未来为患非酒精性脂肪肝和糖尿病风险增加的儿童进行预防工作。

Abstract Nonalcoholic fatty liver disease (NAFLD) is an obesity-associated liver disease that affects an estimated 7 million children in the United States. It is the most common reason for liver transplantation in adults and increases long term risk of diabetes and cardiovascular disease. NAFLD disproportionately affects Hispanic children and is an exceptionally important health disparity. The original R01 study focuses on use of a low sugar diet intervention for prevention of NAFLD in pre-pubertal children. The proposed administrative supplement studies are designed to expand the project to siblings of the primary participant and to add assessment of response of diabetes risk factors to the intervention. The findings will have sustained and significant implications for health promotion in Hispanic children, reduce health disparities, and inform future prevention efforts for children at increased risk of NAFLD and diabetes.