Tailoring Recruitment Communication using Virtual Human Technology to Increase Participation of Older Minority Adults in Clinical Trials

项目总结 老年少数群体是未得到充分服务的人群，他们患慢性病的风险特别高。 疾病/健康状况，在临床研究中的比例明显偏低。众所周知的障碍， 包括与研究相关的不信任(例如，认为参与者缺乏选择，不信任白人研究人员)，缺乏 CT工作人员的文化多样性/敏感性，以及在决策中排除决策支持提供者- 制定阻碍老年人少数群体参与CT的政策。调整内容和来源首选项以保持耐心- 以文化为中心，对文化敏感(即促进舒适、信任、尊重的感觉)，并与个人相关 接受者(患者)，因此增加了对他们的态度和行为产生持久影响的可能性， 与老年少数群体的积极健康行为有关。这种剪裁还没有被研究过以增加 老年少数群体参与积极的CT的比率，尽管文化上量身定做的VHT干预是 在少数族裔参与者中被认为是值得信赖的。我们的长期目标是增加临床试验(CT) 老年少数群体(黑人/非裔美国人(AA)、西班牙裔/拉丁裔(H/L)和/或 50岁以上的农村成年人)使用虚拟人技术(VHT)。在Aim1，我们将进行聚焦 老年少数族裔团体获得数据，这些数据将被用来重新设计亚历克斯，使其对 这些少数民族。在目标2中，跟踪这些少数群体在不同地区积极参与由NIH资助的CT的情况 远程分娩亚历克斯的方式。在目标3中，我们将比较Alex和标准招聘方法 让这样的少数族裔加入NIH资助的CT。这些项目目标的实现将导致适应性， 为提高活跃期老年少数民族参与率而进行的最低限度量身定制的VHT招募干预 美国国立卫生研究院资助的CTS。

PROJECT SUMMARY Older adult minorities are an underserved population, who are at a particularly high risk for developing chronic diseases/health conditions and are significantly underrepresented in clinical research. Well-known barriers, including research-related mistrust (e.g., belief that participants lack choice, mistrust of white researchers), lack of cultural diversity/sensitivity among CT staff, and the exclusion of decisional support providers in decision- making impede older adult minority participation in CTs. Tailoring content and source preferences to be patient- centered, culturally sensitive (i.e., promote feelings of comfort, trust, respect), and personally relevant to the receiver (a patient), thus increasing the likelihood of having a lasting effect on their attitudes and behaviors, has been linked to positive health behaviors by older adult minorities. Such tailoring has not been studied to increase participation rates of older adult minorities into active CTs, though culturally tailored VHT interventions are perceived as trustworthy among minority participants. Our long-term goal is to increase clinical trial (CT) participation among older adult minorities (Black/African American (AA), Hispanic/Latinx (H/L), and/or rural adults over the age of 50) using Virtual Human Technology (VHT). In Aim1, we will conduct focus groups with older adult minorities to obtain data that will be used to redesign ALEX to be culturally sensitive for these minorities. In Aim 2, track engagement of such minorities into active, NIH-funded CTs across different modalities for remotely delivering ALEX. In Aim 3, we will compare ALEX and standard recruitment methods for enrolling such minorities into NIH-funded CTs. Achievement of these project aims will result in adaptable, minimally tailored VHT recruitment intervention for increasing older adult minority participation rates in active NIH-funded CTs.