Yale Cooperative Center of Excellence in Hematology

摘要 耶鲁血液学卓越合作中心(YCCEH)的目的是促进和 加强非恶性血液学相关研究人员的研究。我们独一无二的 焦点是新兴技术在正常和紊乱的造血研究中的应用。这 包括了解干细胞生物学，造血，包括自我更新的过程， 造血干细胞通过中间祖细胞和前体细胞的扩增和分化 各阶段，不同谱系的分化和功能成熟的血细胞。我们的研究人员 BASE积极参与血液学领域的广泛主题，从干细胞到 骨髓微环境--从血液病发病机制的认识到发展 对遗传性和获得性疾病的新治疗策略，通过输注红细胞和 对血小板相关并发症进行研究。同时，跨基督教青年会利用的特定技术 反映了这种多样性，利用了许多领域的技术，包括细胞信号、基因组学、 蛋白质组学、RNA生物学、分子生物学、高级成像和显微镜，以更好地了解 血液学过程。耶鲁大学医学院的资源和环境 由于以下方面的兴趣和专业知识，一直并将继续非常适合该中心 它的许多教员在血液学、干细胞生物学、基因组分析和生物信息学领域。 耶鲁大学现有的大量核心设施的可用性，这些设施直接与耶鲁大学的 核心，如耶鲁干细胞中心，耶鲁基因组分析中心，耶鲁大学中心 临床调查，耶鲁医学信息学中心，耶鲁高性能中心 生物医学中的计算、耶鲁系统生物学研究所和新成立的德卢卡中心 对于血液学研究，进一步协同整个大学的血液学研究。加在一起，这些 资源支持许多与血液学研究人员相关的关键核心设施。基督教青年会将 通过提供培训和专业知识，继续为我们的研究基地(耶鲁大学和外部)提供服务 通过新兴技术研究中心，同时提供更多的教育机会 以及通过浓缩核心的相互作用。新兴技术研究核心不仅将 通过提供获取尖端技术的途径来加强研究，但也提高了成本效益 得到资助的研究。青年会的长期目标是在以下综合计划中发挥关键作用 其他NIDDK合作中心提供的血液病相关研究支持 通过提供机会促进我们内部的合作，在血液学方面取得卓越成就 研究基地和其他机构的研究人员，支持广泛和深入的血液学 疾病研究基地。

Abstract The purpose of the Yale Cooperative Center of Excellence in Hematology (YCCEH) is to facilitate and enhance research by investigators engaged in nonmalignant hematology-related research. Our unique focus is the application of emerging technologies to the study of normal and perturbed hematopoiesis. This includes understanding stem cell biology, hematopoiesis, including the processes of self renewal, expansion and differentiation of hematopoietic stem cells, through intermediate progenitor and precursor stages, to mature differentiated and functional blood cells of different lineages. Members of our Research Base are actively engaged in a wide range of topics in the field of hematology, from the stem cell to the bone marrow microenvironment, from understanding mechanisms of hematologic disease to development of novel therapeutic strategies for inherited and acquired disorders, from transfusion of red blood cells and platelets to study of related complications. In parallel, specific technologies utilized across the YCCEH reflect this diversity, with techniques from many fields utilized including cell signaling, genomics, proteomics, RNA biology, molecular biology, advanced imaging and microscopy, to better understand hematologic processes. The resources and environment of the Yale University School of Medicine have been and continue to be particularly well suited to the Center because of the interests and expertise of many of its faculty in the areas of hematology, stem cell biology, genomic analyses and bioinformatics. The availability of a large range of existing core facilities at Yale that directly interface with the YCCEH’s cores, such as the Yale Stem Cell Center, the Yale Center for Genome Analysis, the Yale Center for Clinical Investigation, the Yale Center for Medical Informatics, the Yale Center for High-Performance Computation in Biomedicine, the Yale Systems Biology Institute and the newly established DeLuca Center for Research in Hematology further synergize hematology research across the university. Together, these resources support numerous critical core facilities relevant to hematology investigators. The YCCEH will continue to serve our Research Base (both at Yale and external) by providing training and expertise through the Emerging Technology Research Cores, while providing enhanced opportunities for education and interactions through the Enrichment Core. The Emerging Technology Research Cores will not only enhance research by providing access to cutting edge technologies, but also improve cost-effectiveness of supported research. The long term goal of the YCCEH is to play a key role in the integrated program of hematologic diseases-related research support provided by other NIDDK Cooperative Centers of Excellence in Hematology by providing opportunities to promote increased collaboration within our Research Base and with investigators at other institutions, supporting a broad and deep hematologic diseases research base.