Training in Cardiovascular Imaging Research

项目主任/首席调查员(最后、第一、中间)：克莱默，克里斯托弗·M。 心血管疾病是美国发病率和死亡率的主要原因。事实上，43%的 所有的死亡都是由冠心病和心力衰竭引起的，预计患病率会增加 在2012至2030年间下降了46%。需要改进的非侵入性方法来检测早期疾病和 因此，帮助管理慢性病患者从未像现在这样重要。技术上的进步 近年来，非侵入性心血管成像技术的应用越来越广泛。核心脏病学和 超声心动图是临床上常用的成熟技术。心血管磁化 磁共振成像(CMR)、计算机断层血管成像(CTA)和正电子发射断层扫描 (PET)在心血管疾病的临床评估中发挥着越来越大的作用，并且对心血管疾病来说是相对较新的 培训计划。在物理、工程和医疗领域拥有深厚专业知识的医生人数 分子在所有5种主要心血管成像方式中的应用仍然有限。弗吉尼亚大学 弗吉尼亚大学(UVA)是美国少数几个拥有高水平临床、物理、工程和分子技术的中心之一 在所有心血管成像设备方面的专业知识，以及在研究方面培训医生的记录。 在过去的十年里，受训人员在出版方面取得了很高的生产力，其中一半人继续 在美国各地杰出机构的学术生涯。两名前实习生加入了UVA教职员工和 都是由NIH资助的，总共有2个K23奖和1个R01奖。这项拨款续期建议的目的 是继续并进一步发展提供心血管综合培训的培训方案 影像研究。该项目为学员提供了与成像密切互动的绝佳机会 物理学家和工程师，他们共同承诺改进两种临床应用 这些较新的技术以及平移成像的进一步发展和应用。实习生有 来自一位博士影像科学家和一位MD临床研究员的双重指导。培训的目标是 培养心血管成像领域的下一代学术研究人员，他们可以与 纪律。受训者在经历了两年的临床培训后，将接受为期两年的严格的研究培训计划 在弗吉尼亚大学完成心血管培训计划或在其他机构完成为期3年的计划。向上 任何时候都可以招收3名研究员。提供了一个完整的教学计划，包括成像方面的指导 物理学与工程学、生物统计学、流行病学、临床研究方法论和医学伦理学。研究员 接受临床CMR、CTA和PET方面的培训。研究培训是全面的，结合了临床和 为每名学员提供任何一种方式的基础心血管成像研究。 PHS 398/2590(06/09版)页面续格式页面

Program Director/Principal Investigator (Last, First, Middle): Kramer, Christopher M. Cardiovascular disease is the major cause of morbidity and mortality in the United States. In fact, 43% of all deaths are due to coronary heart disease and heart failure is on the rise, expecting to increase in prevalence by 46% between 2012 and 2030. The need for improved noninvasive methods to detect early disease and to help manage patients with chronic disease has therefore never been as critical. Technical advances in noninvasive cardiovascular imaging have resulted in increasing use over recent years. Nuclear cardiology and echocardiography are mature technologies that are commonly used in clinical practice. Cardiovascular magnetic resonance imaging (CMR), computed tomographic angiography (CTA), and positron emission tomography (PET) are playing a growing role in the clinical assessment of CVD and are relatively new to cardiovascular training programs. The number of physicians who have in-depth expertise in the physics, engineering, and molecular applications in all 5 major cardiovascular imaging modalities remains limited. The University of Virginia (UVA) is one of a handful of centers in the U.S. that have high-level clinical, physics, engineering, and molecular expertise in all cardiovascular imaging modalities, as well as a track record of training physicians in research. Over the past decade, trainees have been highly productive in terms of publication and half have gone on to academic careers in outstanding institutions around the U.S. Two former trainees joined the UVA faculty and have been NIH-funded, with 2 K23 and 1 R01 awards between them. The purpose of this grant renewal proposal is to continue and further develop the training program that provides comprehensive training in cardiovascular imaging research. The program provides trainees with outstanding opportunities to interact closely with imaging physicists and engineers who together offer the promise of improvements in both the clinical applications of these newer technologies and further development of and applications of translational imaging. Trainees have dual mentorship from a PhD imaging scientist and a MD clinician investigator. The goal of the training is to develop the next generation of academic investigators in cardiovascular imaging who can interact across disciplines. Trainees undergo a rigorous 2-year research training program following a 2-year clinical cardiovascular training program completed at the UVA or a 3-year program completed at another institution. Up to 3 fellows are enrolled at any one time. A complete didactic program is offered including instruction in imaging physics and engineering, biostatistics, epidemiology, clinical research methodology, and medical ethics. Fellows receive training in clinical CMR, CTA, and PET. Research training is comprehensive and combines clinical and basic cardiovascular imaging research for each trainee with any of the modalities. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page