Engineering Core

工程核心 工程核心的目标是使我们的团队成员能够克服他们最具挑战性的 技术和工程障碍。在我们的提案中有很多工程解决方案的需求-- 从行为仪器到光学和电生理设备，再到数据采集软件， 分析。即使是我们团队中技术最先进的研究小组， 帮助解决工程问题，以实现我们的宏伟目标。在脑科学中心 在哈佛，现有的工程核心包括 (a)一个综合实验室，设计，原型，测试和生产神经科学的定制设备 实验 和 (b)Brett Graham博士是一位工程师神经科学家，他解决了世界上最具挑战性的工程问题。 用户实验室和培训年轻科学家自己做这件事。 通过增加一名专门的工程师，工程核心能够支持基于团队的神经科学 这里提出的研究。具体目标是实施工程解决方案所面临的问题 项目和其他核心。工程核心将（a）设计和建造快速成像的设备 游泳的斑马鱼幼体;（B）构建钻机以通过以下方式记录斑马鱼幼体大脑和心脏中的神经活动： 钙成像;以及（c）进一步使连接组学成像流水线自动化。

Engineering Core The goal of the Engineering Core is to enable our Team members to surmount their most challenging technological and engineering obstacles. There are many needs for engineering solutions in our proposal -- from behavioral apparatus to optical and electrophysiological rigs, to software for data acquisition and analyses. Even the most technologically sophisticated of the research groups in our Team require special assistance with engineering problems in order to achieve our ambitious aims. In the Center for Brain Science at Harvard there is an existing Engineering Core that consists of (a) an integrated laboratory to design, prototype, iterate, and produce custom devices for neuroscience experiments and (b) Dr. Brett Graham, an engineer-neuroscientist who solves the most challenging engineering problems in the user laboratories and trains young scientists to do this themselves. By adding a dedicated staff engineer, the Engineering Core is able to support the team-based neuroscience research proposed here. The specific aims are to implement engineering solutions to problems faced by the Projects and other Cores. The Engineering Core will (a) design and build apparatuses to image rapidly swimming larval zebrafish; (b) build rigs to record neural activity in larval zebrafish brains and hearts via calcium imaging; and (c) further automate the connectomics imaging pipeline.