Center for Childhood Obesity Prevention

项目总结 该应用程序的目标是进一步发展一个综合的、多学科的和翻译的中心 儿童肥胖预防(CCOP)将在阿肯色州儿童基金会内持续进行 研究所。儿童肥胖是一个全国性的公共健康威胁，在 阿肯色州。在美国，近五分之一的学龄青年患有肥胖症(1)。年的学龄青年中 阿肯色州有23%的人肥胖，17%的人超重(2)。此外，高血压的患病率 (4-6)和其他与肥胖相关的共病在过去20年里急剧增加。 此外，肥胖和促进肥胖的行为也与多种癌症有关(16)。致信地址 这个复杂的问题，一组在第一阶段招募的新兴科学家将继续建立他们的 在阐明原因和测试干预措施方面进行协作，以阻止这种上升并最终减少 儿童超重和肥胖以及相应的合并症的患病率。 为了建立一个基础广泛、多学科、扎根于团队的疾病预防中心 科学方法，项目跨越整个翻译连续体，将复杂的研究汇集在一起 疾病起源、流行病学和社会制度。正在招聘更多的研究项目负责人 试点研究调查人员将继续建立一支关键的科学家队伍，专注于建立 为解决儿童肥胖危机和改善儿童健康的战略提供证据。 具体目标1：进一步加强在第一阶段建立的研究基础设施，以支持 中心。关键的机构支持以及与多个关键机构和社区的强大协作 已经建立并将继续加强合作伙伴，为初级调查人员提供 最先进的生物医学研究设施和资源，以研究为重点的主题 预防儿童肥胖。 具体目标2：继续在成功实施的教师发展方案的基础上再接再厉 在第一阶段。与UAMS合作在第一阶段建立的职业发展培训方案 CTSA的研究基础计划将继续得到加强。“最佳实践”高级指导 计划将高级导师的权利和责任合同与高级导师的指导相结合 指导领导团队的方法。 具体目标3：确保中心的稳健运作和实现可持续性的途径 预防儿童肥胖。全面的运营程序，用于管理中心的财务、 法规、项目开发和研究的核心可行性流程已经建立，并将继续 得到加强。已获得大量机构投资，并将利用这些投资确保长期 中心的长期可持续性。

PROJECT SUMMARY The goal of this application is to further develop an integrated, multidisciplinary and translational Center for Childhood Obesity Prevention (CCOP) that will be sustained within the Arkansas Children’s Research Institute. Childhood obesity is a national public health threat that is disproportionately worse in Arkansas. In the United States, nearly 1 in 5 school age youth have obesity (1). Among school-age youth in Arkansas, 23% have obesity and 17% are classified as overweight (2). Further, the prevalence of hypertension (4-6), and other obesity-related co-morbidities, have increased dramatically over the last two decades. Additionally, obesity and obesity-promoting behaviors are also linked to a variety of cancers (16). To address this complex problem, a group of emerging scientists recruited in Phase 1 will continue to build their collaborative work in elucidating causes, and testing interventions, to stop the rise and ultimately reduce the prevalence of child overweight and obesity and corresponding comorbidities. In order to establish a broad-based, multi-disciplinary disease prevention center, rooted in a team science approach, projects span the full translational continuum, bringing together research in complex disease origins, epidemiology, and social systems. Ongoing recruitment of additional research project leaders and pilot study investigators will continue to build a critical mass of scientists focused on building the base of evidence for strategies to address the childhood obesity crisis and improve child health. Specific Aim 1: Further enhance the research infrastructure established in Phase 1 to support the Center. Critical institutional support and strong collaborations with multiple key institutional and community partners have been established, and will continue to be enhanced, to provide junior investigators’ access to state-of-the-art biomedical research facilities and resources to pursue inquiry focused on the theme of childhood obesity prevention. Specific Aim 2: Continue to build on the successful faculty development program implemented in Phase 1. The career development training program established in Phase 1 in partnership with the UAMS CTSA’s Research Fundamentals program will continue to be strengthened. A “best practices” senior mentoring program combines a Senior Mentor Rights and Responsibilities contract with guidance from a Senior Mentoring Leadership Team approach. Specific Aim 3: Ensure robust operations and pathway to sustainability for the Center for Childhood Obesity Prevention. Comprehensive operational procedures for managing the Center’s fiscal, regulatory, project development, and research core viability processes were established, and will continue to be strengthened. Significant institutional investment has been secured, and will be leveraged to ensure long term sustainability of the Center.