Fabrication and Testing of a Novel PET insert for Simultaneous PET/MRI

项目摘要。正电子发射断层扫描是目前可用的最灵敏的成像手段。 它既可以用于小动物，也可以用于人类。我们建议与我们的工业界和学术界建立 与基于单晶管的新一代PET扫描仪(ScintoTube-ST-PET)合作。这将是 有效去除当前一代PET扫描仪的边缘。在边缘处有扭曲 有效降低空间分辨率和灵敏度的扫描仪元件。提议扫描仪已被 设计并将用于磁共振成像(MRI)扫描仪。这是一个 学术/产业伙伴关系补助金。弗吉尼亚大学(UVA)将领导该项目。他们的合作伙伴 包括i3M(CSIC-西班牙国家研究理事会)和Bruker Española。UVA团队拥有专业知识 在测试/验证新型PET扫描仪时，MRI软件(PULSE编程)和硬件设计，以及 小鼠正电子发射计算机断层扫描和磁共振成像。I3m和他们在Bruker的同事在设计方面拥有丰富的专业知识 以及建造多模式扫描仪，包括白三模PET/SPECT/CT鼠标扫描仪。大部分 ST-PET扫描仪所需的技术已由i3M/Bruker开发，并将作为 这个项目的一部分给了ST-PET。本文的工作包括：(1)制作高场用ST-PET插入体 核磁共振扫描仪。插件将由i3M和Bruker实现。ST-PET扫描仪的测试与验证 在磁铁之外，首先是i3M，然后是UVA。(2)将ST-PET插件与7T集成并进行测试 UVA的ClinScan核磁共振成像。(3)作为原理验证项目，使用新开发的ST-PET/MRI进行成像 肺癌在小鼠模型中的进展和转移。

Project Summary. PET (positron emission tomography) is the most sensitive imaging modality available that can be used both for small animals and humans. We propose to build with our industrial and academic partners a new generation of PET scanners based on a single crystal tube (ScintoTube – ST‐PET). This will effectively remove edges from current generation PET scanners. There are distortions at the edges of scanner elements that effectively reduce spatial resolution and sensitivity. The propose scanner has been designed and will be built to be used in a magnetic resonance imaging (MRI) scanner. This is an Academic/Industrial partnership grant. The University of Virginia (UVa) will lead the project. Their partners include i3M (CSIC ‐ Spanish National Research Council) and Bruker Española. The UVa team has expertise in testing/validating novel PET scanners, MRI software (pulse programming) and hardware design, and mouse PET and MRI scanning. I3M and their colleagues at Bruker have a wealth of expertise in designing and building multimodal scanners, including the Albira trimodal PET/SPECT/CT mouse scanner. Much of the technology needed for the ST‐PET scanner has been developed by i3M/Bruker and will be ported as part of this project to the ST‐PET. The proposed work includes: (1) Fabricate a ST‐PET insert for a high field MRI scanner. The insert will be implemented by i3M and Bruker. Test and validate the ST‐PET scanner outside the magnet first at i3M and then at UVa. (2) Integrate and test the ST‐PET insert with the 7T ClinScan MRI at UVa. (3) As a proof‐of‐principle project, use the newly developed ST‐PET/MRI to image lung cancer progression and metastasis in a mouse model.